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Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes

Facial nerve (FN) injury can lead to debilitating and permanent facial paresis/paralysis (FP), where facial muscles progressively lose tone, atrophy, and ultimately reduce to scar tissue. Despite considerable efforts in the recent decades, therapies for FP still possess high failure rates and provid...

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Autores principales: Abiri, Arash, Chau, Steven, James, Nathan R., Goshtasbi, Khodayar, Birkenbeuel, Jack L., Sahyouni, Ronald, Edwards, Robert, Djalilian, Hamid R., Lin, Harrison W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688741/
https://www.ncbi.nlm.nih.gov/pubmed/36358383
http://dx.doi.org/10.3390/brainsci12111457
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author Abiri, Arash
Chau, Steven
James, Nathan R.
Goshtasbi, Khodayar
Birkenbeuel, Jack L.
Sahyouni, Ronald
Edwards, Robert
Djalilian, Hamid R.
Lin, Harrison W.
author_facet Abiri, Arash
Chau, Steven
James, Nathan R.
Goshtasbi, Khodayar
Birkenbeuel, Jack L.
Sahyouni, Ronald
Edwards, Robert
Djalilian, Hamid R.
Lin, Harrison W.
author_sort Abiri, Arash
collection PubMed
description Facial nerve (FN) injury can lead to debilitating and permanent facial paresis/paralysis (FP), where facial muscles progressively lose tone, atrophy, and ultimately reduce to scar tissue. Despite considerable efforts in the recent decades, therapies for FP still possess high failure rates and provide inadequate recovery of muscle function. In this pilot study, we used a feline model to demonstrate the potential for chronically implanted multichannel dual-cuff electrodes (MCE) to selectively stimulate injured facial nerves at low current intensities to avoid stimulus-induced neural injury. Selective facial muscle activation was achieved over six months after FN injury and MCE implantation in two domestic shorthaired cats (Felis catus). Through utilization of bipolar stimulation, specific muscles were activated at significantly lower electrical currents than was achievable with single channel stimulation. Moreover, interval increases in subthreshold current intensities using bipolar stimulation enabled a graded EMG voltage response while maintaining muscle selectivity. Histological examination of neural tissue at implant sites showed no appreciable signs of stimulation-induced nerve injury. Thus, by selectively activating facial musculature six months following initial FN injury and MCE implantation, we demonstrated the potential for our neural stimulator system to be safely and effectively applied to the chronic setting, with implications for FP treatment.
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spelling pubmed-96887412022-11-25 Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes Abiri, Arash Chau, Steven James, Nathan R. Goshtasbi, Khodayar Birkenbeuel, Jack L. Sahyouni, Ronald Edwards, Robert Djalilian, Hamid R. Lin, Harrison W. Brain Sci Article Facial nerve (FN) injury can lead to debilitating and permanent facial paresis/paralysis (FP), where facial muscles progressively lose tone, atrophy, and ultimately reduce to scar tissue. Despite considerable efforts in the recent decades, therapies for FP still possess high failure rates and provide inadequate recovery of muscle function. In this pilot study, we used a feline model to demonstrate the potential for chronically implanted multichannel dual-cuff electrodes (MCE) to selectively stimulate injured facial nerves at low current intensities to avoid stimulus-induced neural injury. Selective facial muscle activation was achieved over six months after FN injury and MCE implantation in two domestic shorthaired cats (Felis catus). Through utilization of bipolar stimulation, specific muscles were activated at significantly lower electrical currents than was achievable with single channel stimulation. Moreover, interval increases in subthreshold current intensities using bipolar stimulation enabled a graded EMG voltage response while maintaining muscle selectivity. Histological examination of neural tissue at implant sites showed no appreciable signs of stimulation-induced nerve injury. Thus, by selectively activating facial musculature six months following initial FN injury and MCE implantation, we demonstrated the potential for our neural stimulator system to be safely and effectively applied to the chronic setting, with implications for FP treatment. MDPI 2022-10-27 /pmc/articles/PMC9688741/ /pubmed/36358383 http://dx.doi.org/10.3390/brainsci12111457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abiri, Arash
Chau, Steven
James, Nathan R.
Goshtasbi, Khodayar
Birkenbeuel, Jack L.
Sahyouni, Ronald
Edwards, Robert
Djalilian, Hamid R.
Lin, Harrison W.
Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title_full Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title_fullStr Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title_full_unstemmed Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title_short Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes
title_sort selective neural electrical stimulation of an injured facial nerve using chronically implanted dual cuff electrodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688741/
https://www.ncbi.nlm.nih.gov/pubmed/36358383
http://dx.doi.org/10.3390/brainsci12111457
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