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Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease

Background: After deep brain stimulation (DBS), hiccups as a complication may lead to extreme fatigue, sleep deprivation, or affected prognosis. Currently, the causes and risk factors of postoperative hiccups are unclear. In this study, we investigated the risk factors for hiccups after DBS of the s...

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Autores principales: Wu, Bin, Ling, Yuting, Zhang, Changming, Liu, Yi, Xuan, Ruoheng, Xu, Jiakun, Li, Yongfu, Guo, Qianqian, Wang, Simin, Liu, Lige, Jiang, Lulu, Huang, Zihuan, Chu, Jianping, Chen, Ling, Jiang, Nan, Liu, Jinlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688754/
https://www.ncbi.nlm.nih.gov/pubmed/36358373
http://dx.doi.org/10.3390/brainsci12111447
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author Wu, Bin
Ling, Yuting
Zhang, Changming
Liu, Yi
Xuan, Ruoheng
Xu, Jiakun
Li, Yongfu
Guo, Qianqian
Wang, Simin
Liu, Lige
Jiang, Lulu
Huang, Zihuan
Chu, Jianping
Chen, Ling
Jiang, Nan
Liu, Jinlong
author_facet Wu, Bin
Ling, Yuting
Zhang, Changming
Liu, Yi
Xuan, Ruoheng
Xu, Jiakun
Li, Yongfu
Guo, Qianqian
Wang, Simin
Liu, Lige
Jiang, Lulu
Huang, Zihuan
Chu, Jianping
Chen, Ling
Jiang, Nan
Liu, Jinlong
author_sort Wu, Bin
collection PubMed
description Background: After deep brain stimulation (DBS), hiccups as a complication may lead to extreme fatigue, sleep deprivation, or affected prognosis. Currently, the causes and risk factors of postoperative hiccups are unclear. In this study, we investigated the risk factors for hiccups after DBS of the subthalamic nucleus (STN) for Parkinson’s disease (PD) under general anesthesia. Methods: We retrospectively included patients who underwent STN DBS in the study, and collected data of demographic characteristics, clinical evaluations, and medications. According to the occurrence of hiccups within seven days after operation, the patients were divided into a hiccups group and non-hiccups group. The potentially involved risk factors for postoperative hiccups were statistically analyzed by logistic regression analysis. Results: A total of 191 patients were included in the study, of which 34 (17.80%) had postoperative transient persistent hiccups. Binary univariate logistic regression analysis showed that male, higher body mass index (BMI), smoker, Hoehn and Yahr stage (off), preoperative use of amantadine, hypnotic, Hamilton anxiety scale and Hamilton depression scale scores, and postoperative limited noninfectious peri-electrode edema in deep white matter were suspected risk factors for postoperative hiccups (p < 0.1). In binary multivariate logistic regression analysis, male (compared to female, OR 14.00; 95% CI, 1.74–112.43), postoperative limited noninfectious peri-electrode edema in deep white matter (OR, 7.63; 95% CI, 1.37–42.37), preoperative use of amantadine (OR, 3.64; 95% CI, 1.08–12.28), and higher BMI (OR, 3.50; 95% CI, 1.46–8.36) were independent risk factors for postoperative hiccups. Conclusions: This study is the first report about the risk factors of hiccups after STN DBS under general anesthesia for PD patients. The study suggests that male, higher BMI, preoperative use of amantadine, and postoperative limited noninfectious peri-electrode edema in deep white matter are independent risk factors for postoperative hiccups of STN-DBS for PD patients. Most hiccups after STN-DBS for PD patients were transient and self-limiting.
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spelling pubmed-96887542022-11-25 Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease Wu, Bin Ling, Yuting Zhang, Changming Liu, Yi Xuan, Ruoheng Xu, Jiakun Li, Yongfu Guo, Qianqian Wang, Simin Liu, Lige Jiang, Lulu Huang, Zihuan Chu, Jianping Chen, Ling Jiang, Nan Liu, Jinlong Brain Sci Article Background: After deep brain stimulation (DBS), hiccups as a complication may lead to extreme fatigue, sleep deprivation, or affected prognosis. Currently, the causes and risk factors of postoperative hiccups are unclear. In this study, we investigated the risk factors for hiccups after DBS of the subthalamic nucleus (STN) for Parkinson’s disease (PD) under general anesthesia. Methods: We retrospectively included patients who underwent STN DBS in the study, and collected data of demographic characteristics, clinical evaluations, and medications. According to the occurrence of hiccups within seven days after operation, the patients were divided into a hiccups group and non-hiccups group. The potentially involved risk factors for postoperative hiccups were statistically analyzed by logistic regression analysis. Results: A total of 191 patients were included in the study, of which 34 (17.80%) had postoperative transient persistent hiccups. Binary univariate logistic regression analysis showed that male, higher body mass index (BMI), smoker, Hoehn and Yahr stage (off), preoperative use of amantadine, hypnotic, Hamilton anxiety scale and Hamilton depression scale scores, and postoperative limited noninfectious peri-electrode edema in deep white matter were suspected risk factors for postoperative hiccups (p < 0.1). In binary multivariate logistic regression analysis, male (compared to female, OR 14.00; 95% CI, 1.74–112.43), postoperative limited noninfectious peri-electrode edema in deep white matter (OR, 7.63; 95% CI, 1.37–42.37), preoperative use of amantadine (OR, 3.64; 95% CI, 1.08–12.28), and higher BMI (OR, 3.50; 95% CI, 1.46–8.36) were independent risk factors for postoperative hiccups. Conclusions: This study is the first report about the risk factors of hiccups after STN DBS under general anesthesia for PD patients. The study suggests that male, higher BMI, preoperative use of amantadine, and postoperative limited noninfectious peri-electrode edema in deep white matter are independent risk factors for postoperative hiccups of STN-DBS for PD patients. Most hiccups after STN-DBS for PD patients were transient and self-limiting. MDPI 2022-10-26 /pmc/articles/PMC9688754/ /pubmed/36358373 http://dx.doi.org/10.3390/brainsci12111447 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Bin
Ling, Yuting
Zhang, Changming
Liu, Yi
Xuan, Ruoheng
Xu, Jiakun
Li, Yongfu
Guo, Qianqian
Wang, Simin
Liu, Lige
Jiang, Lulu
Huang, Zihuan
Chu, Jianping
Chen, Ling
Jiang, Nan
Liu, Jinlong
Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title_full Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title_fullStr Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title_full_unstemmed Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title_short Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
title_sort risk factors for hiccups after deep brain stimulation of subthalamic nucleus for parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688754/
https://www.ncbi.nlm.nih.gov/pubmed/36358373
http://dx.doi.org/10.3390/brainsci12111447
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