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AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys

N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson’s disease patients, but the use of antagonists that directly inhibit this receptor is associated with severe side effects. L-4-chlorokynurenine (4-Cl-KYN or AV-101) is a pro-drug of 7-chloroky...

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Detalles Bibliográficos
Autores principales:	Bourque, Mélanie, Grégoire, Laurent, Patel, Waseema, Dickens, David, Snodgrass, Ralph, Di Paolo, Thérèse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688762/ https://www.ncbi.nlm.nih.gov/pubmed/36428960 http://dx.doi.org/10.3390/cells11223530

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