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A Sweet Warning: Mucin-Type O-Glycans in Cancer
Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688771/ https://www.ncbi.nlm.nih.gov/pubmed/36429094 http://dx.doi.org/10.3390/cells11223666 |
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author | Zhang, Yuhan Sun, Lingbo Lei, Changda Li, Wenyan Han, Jiaqi Zhang, Jing Zhang, Yuecheng |
author_facet | Zhang, Yuhan Sun, Lingbo Lei, Changda Li, Wenyan Han, Jiaqi Zhang, Jing Zhang, Yuecheng |
author_sort | Zhang, Yuhan |
collection | PubMed |
description | Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed. |
format | Online Article Text |
id | pubmed-9688771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96887712022-11-25 A Sweet Warning: Mucin-Type O-Glycans in Cancer Zhang, Yuhan Sun, Lingbo Lei, Changda Li, Wenyan Han, Jiaqi Zhang, Jing Zhang, Yuecheng Cells Review Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed. MDPI 2022-11-18 /pmc/articles/PMC9688771/ /pubmed/36429094 http://dx.doi.org/10.3390/cells11223666 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Yuhan Sun, Lingbo Lei, Changda Li, Wenyan Han, Jiaqi Zhang, Jing Zhang, Yuecheng A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title_full | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title_fullStr | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title_full_unstemmed | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title_short | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
title_sort | sweet warning: mucin-type o-glycans in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688771/ https://www.ncbi.nlm.nih.gov/pubmed/36429094 http://dx.doi.org/10.3390/cells11223666 |
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