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Minor Kinases with Major Roles in Cytokinesis Regulation

Cytokinesis, the conclusive act of cell division, allows cytoplasmic organelles and chromosomes to be faithfully partitioned between two daughter cells. In animal organisms, its accurate regulation is a fundamental task for normal development and for preventing aneuploidy. Cytokinesis failures produ...

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Autores principales: Sechi, Stefano, Piergentili, Roberto, Giansanti, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688779/
https://www.ncbi.nlm.nih.gov/pubmed/36429067
http://dx.doi.org/10.3390/cells11223639
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author Sechi, Stefano
Piergentili, Roberto
Giansanti, Maria Grazia
author_facet Sechi, Stefano
Piergentili, Roberto
Giansanti, Maria Grazia
author_sort Sechi, Stefano
collection PubMed
description Cytokinesis, the conclusive act of cell division, allows cytoplasmic organelles and chromosomes to be faithfully partitioned between two daughter cells. In animal organisms, its accurate regulation is a fundamental task for normal development and for preventing aneuploidy. Cytokinesis failures produce genetically unstable tetraploid cells and ultimately result in chromosome instability, a hallmark of cancer cells. In animal cells, the assembly and constriction of an actomyosin ring drive cleavage furrow ingression, resulting in the formation of a cytoplasmic intercellular bridge, which is severed during abscission, the final event of cytokinesis. Kinase-mediated phosphorylation is a crucial process to orchestrate the spatio-temporal regulation of the different stages of cytokinesis. Several kinases have been described in the literature, such as cyclin-dependent kinase, polo-like kinase 1, and Aurora B, regulating both furrow ingression and/or abscission. However, others exist, with well-established roles in cell-cycle progression but whose specific role in cytokinesis has been poorly investigated, leading to considering these kinases as “minor” actors in this process. Yet, they deserve additional attention, as they might disclose unexpected routes of cell division regulation. Here, we summarize the role of multifunctional kinases in cytokinesis with a special focus on those with a still scarcely defined function during cell cleavage. Moreover, we discuss their implication in cancer.
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spelling pubmed-96887792022-11-25 Minor Kinases with Major Roles in Cytokinesis Regulation Sechi, Stefano Piergentili, Roberto Giansanti, Maria Grazia Cells Review Cytokinesis, the conclusive act of cell division, allows cytoplasmic organelles and chromosomes to be faithfully partitioned between two daughter cells. In animal organisms, its accurate regulation is a fundamental task for normal development and for preventing aneuploidy. Cytokinesis failures produce genetically unstable tetraploid cells and ultimately result in chromosome instability, a hallmark of cancer cells. In animal cells, the assembly and constriction of an actomyosin ring drive cleavage furrow ingression, resulting in the formation of a cytoplasmic intercellular bridge, which is severed during abscission, the final event of cytokinesis. Kinase-mediated phosphorylation is a crucial process to orchestrate the spatio-temporal regulation of the different stages of cytokinesis. Several kinases have been described in the literature, such as cyclin-dependent kinase, polo-like kinase 1, and Aurora B, regulating both furrow ingression and/or abscission. However, others exist, with well-established roles in cell-cycle progression but whose specific role in cytokinesis has been poorly investigated, leading to considering these kinases as “minor” actors in this process. Yet, they deserve additional attention, as they might disclose unexpected routes of cell division regulation. Here, we summarize the role of multifunctional kinases in cytokinesis with a special focus on those with a still scarcely defined function during cell cleavage. Moreover, we discuss their implication in cancer. MDPI 2022-11-17 /pmc/articles/PMC9688779/ /pubmed/36429067 http://dx.doi.org/10.3390/cells11223639 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sechi, Stefano
Piergentili, Roberto
Giansanti, Maria Grazia
Minor Kinases with Major Roles in Cytokinesis Regulation
title Minor Kinases with Major Roles in Cytokinesis Regulation
title_full Minor Kinases with Major Roles in Cytokinesis Regulation
title_fullStr Minor Kinases with Major Roles in Cytokinesis Regulation
title_full_unstemmed Minor Kinases with Major Roles in Cytokinesis Regulation
title_short Minor Kinases with Major Roles in Cytokinesis Regulation
title_sort minor kinases with major roles in cytokinesis regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688779/
https://www.ncbi.nlm.nih.gov/pubmed/36429067
http://dx.doi.org/10.3390/cells11223639
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