Dual Optical Nanosensor Based on Ormosil Nanoparticles for Monitoring O(2) and pH

Monitoring O(2) and pH has excellent potential in different sensing applications, especially in biological and clinical applications. This report presents a protocol for synthesizing an optical dual nanosensor for those two parameters. The organically modified silica (ormosil) nanoparticles were prepared based on phenytrimethoxysilane in an aqueous solution using an acid-base one-pot strategy. Ormosil was selected as a lipophilic matrix for loading fluorescent O(2)-sensitive dye platinum(II)-tetrakis-(pentafluorophenyl) porphyrin (Pt-TPFPP), which was quenched in the presence of O(2) gas and exhibited a considerable detection proficiency within a percentage range of (0–100%) O(2). Commercially available drug ingredient salicylamide was labeled on the surface of the nanoparticles using a coupling agent (3-glycidoxypropyl) trimethoxysilane (GPTMS). For measuring pH, salicylamide acted for the first time as a pH-sensitive probe based on a turn-on process with increasing pH. The nanosensor displayed a significant pH detection efficiency in the range of (pH = 6–10). Salicylamide turn-on fluorescence was attributed to the excited state intramolecular transfer (ESIPT) process followed by the inter charge transfer (ICT). The presented dual nanosensor opens new opportunities as a promising candidate material for industrial systems and medical applications.