Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for PIK3CA Testing in HR+/HER2− Breast Cancer

Somatic mutations in PIK3CA are present in ~40% breast cancers (BC); their detection in hormone receptor (HR)+/HER2− tumors allows for selecting patients with advanced disease eligible for PIK3CA targeting with alpelisib. The choice of what type of PIK3CA testing approach to adopt and which tissue s...

Descripción completa

Detalles Bibliográficos
Autores principales: Venetis, Konstantinos, Pepe, Francesco, Munzone, Elisabetta, Sajjadi, Elham, Russo, Gianluca, Pisapia, Pasquale, Ivanova, Mariia, Bonizzi, Giuseppina, Vacirca, Davide, Rappa, Alessandra, Ranghiero, Alberto, Taormina, Sergio Vincenzo, Viale, Giuseppe, Troncone, Giancarlo, Barberis, Massimo, Guerini-Rocco, Elena, Malapelle, Umberto, Fusco, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688837/
https://www.ncbi.nlm.nih.gov/pubmed/36428975
http://dx.doi.org/10.3390/cells11223545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688837/
https://www.ncbi.nlm.nih.gov/pubmed/36428975
http://dx.doi.org/10.3390/cells11223545

Ejemplares similares