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Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for PIK3CA Testing in HR+/HER2− Breast Cancer

Somatic mutations in PIK3CA are present in ~40% breast cancers (BC); their detection in hormone receptor (HR)+/HER2− tumors allows for selecting patients with advanced disease eligible for PIK3CA targeting with alpelisib. The choice of what type of PIK3CA testing approach to adopt and which tissue s...

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Detalles Bibliográficos
Autores principales:	Venetis, Konstantinos, Pepe, Francesco, Munzone, Elisabetta, Sajjadi, Elham, Russo, Gianluca, Pisapia, Pasquale, Ivanova, Mariia, Bonizzi, Giuseppina, Vacirca, Davide, Rappa, Alessandra, Ranghiero, Alberto, Taormina, Sergio Vincenzo, Viale, Giuseppe, Troncone, Giancarlo, Barberis, Massimo, Guerini-Rocco, Elena, Malapelle, Umberto, Fusco, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688837/ https://www.ncbi.nlm.nih.gov/pubmed/36428975 http://dx.doi.org/10.3390/cells11223545

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