Cargando…

The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma

We report two patients, one with and one without long-term persistent tiling inside an arcuate macular scotoma. In both cases, the scotoma was caused by a cilioretinal artery occlusion. Both patients were almost identical regarding the location and extent of the scotoma. In both cases, there was a c...

Descripción completa

Detalles Bibliográficos
Autores principales: Gandhewar, Rishikesh, Jurkute, Neringa, Petzold, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688850/
https://www.ncbi.nlm.nih.gov/pubmed/36421866
http://dx.doi.org/10.3390/brainsci12111542
_version_ 1784836373521367040
author Gandhewar, Rishikesh
Jurkute, Neringa
Petzold, Axel
author_facet Gandhewar, Rishikesh
Jurkute, Neringa
Petzold, Axel
author_sort Gandhewar, Rishikesh
collection PubMed
description We report two patients, one with and one without long-term persistent tiling inside an arcuate macular scotoma. In both cases, the scotoma was caused by a cilioretinal artery occlusion. Both patients were almost identical regarding the location and extent of the scotoma. In both cases, there was a comparable degree of atrophy on optical coherence tomography for the retinal nerve fibre, ganglion cell, and inner plexiform layers. The main difference was the preservation of the inner nuclear layer in the patient with persistent tiling. In this patient, optical coherence angiography demonstrates preserved perfusion of the superior vascular plexus, which was not the case in the patient with the negative scotoma who also had atrophy of the inner nuclear layer. Recreational use of cannabinoid enhanced the intensity of perceived tiling in the relative scotoma of the first patient. A review of the literature suggests that the persistent tiling described in our case is different to teichopsias of retinal or cerebral origin. These data suggest that persistent monocular tiling in a scotoma arises from retinal circuit activity that requires the preservation of the inner nuclear layer. Future research should investigate this functional–structural relationship in other diseases, including glaucoma.
format Online
Article
Text
id pubmed-9688850
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96888502022-11-25 The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma Gandhewar, Rishikesh Jurkute, Neringa Petzold, Axel Brain Sci Article We report two patients, one with and one without long-term persistent tiling inside an arcuate macular scotoma. In both cases, the scotoma was caused by a cilioretinal artery occlusion. Both patients were almost identical regarding the location and extent of the scotoma. In both cases, there was a comparable degree of atrophy on optical coherence tomography for the retinal nerve fibre, ganglion cell, and inner plexiform layers. The main difference was the preservation of the inner nuclear layer in the patient with persistent tiling. In this patient, optical coherence angiography demonstrates preserved perfusion of the superior vascular plexus, which was not the case in the patient with the negative scotoma who also had atrophy of the inner nuclear layer. Recreational use of cannabinoid enhanced the intensity of perceived tiling in the relative scotoma of the first patient. A review of the literature suggests that the persistent tiling described in our case is different to teichopsias of retinal or cerebral origin. These data suggest that persistent monocular tiling in a scotoma arises from retinal circuit activity that requires the preservation of the inner nuclear layer. Future research should investigate this functional–structural relationship in other diseases, including glaucoma. MDPI 2022-11-14 /pmc/articles/PMC9688850/ /pubmed/36421866 http://dx.doi.org/10.3390/brainsci12111542 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gandhewar, Rishikesh
Jurkute, Neringa
Petzold, Axel
The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title_full The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title_fullStr The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title_full_unstemmed The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title_short The Role of the Inner Nuclear Layer for Perception of Persisting Tiling Inside a Monocular Scotoma
title_sort role of the inner nuclear layer for perception of persisting tiling inside a monocular scotoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688850/
https://www.ncbi.nlm.nih.gov/pubmed/36421866
http://dx.doi.org/10.3390/brainsci12111542
work_keys_str_mv AT gandhewarrishikesh theroleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma
AT jurkuteneringa theroleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma
AT petzoldaxel theroleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma
AT gandhewarrishikesh roleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma
AT jurkuteneringa roleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma
AT petzoldaxel roleoftheinnernuclearlayerforperceptionofpersistingtilinginsideamonocularscotoma