Cargando…

LRRC8A Is a Promising Prognostic Biomarker and Therapeutic Target for Pancreatic Adenocarcinoma

SIMPLE SUMMARY: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor with a poor prognosis and lack of effective biomarkers. We demonstrated, using bioinformatics analyses, that the leucine-rich repeat-containing 8A (LRRC8A) can affect the prognosis of patients with PAAD. In addition, experi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Rong, Hu, Yaohua, Xie, Qinghua, Zhang, Caiqin, Zhao, Yong, Zhang, He, Shi, Hailong, Wang, Xiaoming, Shi, Changhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688930/ https://www.ncbi.nlm.nih.gov/pubmed/36428619 http://dx.doi.org/10.3390/cancers14225526

Ejemplares similares

LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction
por: Chen, Xiyao, et al.
Publicado: (2022)

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy
por: Widmer, Carmen A., et al.
Publicado: (2022)

MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?
por: Brunetti, Oronzo, et al.
Publicado: (2015)

LRRC8A promotes the initial development of oxaliplatin resistance in colon cancer cells
por: Zhang, Haifeng, et al.
Publicado: (2023)

Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
por: Deneka, Dawid, et al.
Publicado: (2021)

Prognostic significance of LRRC1 in hepatocellular carcinoma and construction of relevant prognostic model
por: Cai, Qingshan, et al.
Publicado: (2023)

Exploiting LRRC15 as a Novel Therapeutic Target in Cancer
por: Ray, Upasana, et al.
Publicado: (2022)

DHX37 Is a Promising Prognostic Biomarker and a Therapeutic Target for Immunotherapy and Chemotherapy in HCC
por: Liu, Nanbin, et al.
Publicado: (2023)

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
por: Green, Jack P, et al.
Publicado: (2020)

Expression of LRRC8/VRAC Currents in Xenopus Oocytes: Advantages and Caveats
por: Gaitán-Peñas, Héctor, et al.
Publicado: (2018)

The LRRC8-mediated volume-regulated anion channel is altered in glaucoma
por: Gasull, Xavier, et al.
Publicado: (2019)

PYCR1: A Potential Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma
por: Wang, Huanyu, et al.
Publicado: (2022)

LRRC59 serves as a novel biomarker for predicting the progression and prognosis of bladder cancer
por: Zhang, Peng, et al.
Publicado: (2023)

Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma
por: Ma, Zuyi, et al.
Publicado: (2021)

Oligoadenylate synthetases-like is a prognostic biomarker and therapeutic target in pancreatic ductal adenocarcinoma
por: Chen, Shihong, et al.
Publicado: (2022)

Lipocalin 2 may be a key factor regulating the chemosensitivity of pancreatic cancer to gemcitabine
por: Zhang, He, et al.
Publicado: (2022)

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes
por: Gaitán-Peñas, Héctor, et al.
Publicado: (2016)

Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8
por: Kasuya, Go, et al.
Publicado: (2022)

Structure of a volume-regulated heteromeric LRRC8A/C channel
por: Rutz, Sonja, et al.
Publicado: (2022)

AQP5 Is a Novel Prognostic Biomarker in Pancreatic Adenocarcinoma
por: Chen, Guo, et al.
Publicado: (2022)

Novel Therapy for Glioblastoma Multiforme by Restoring LRRC4 in Tumor Cells: LRRC4 Inhibits Tumor-Infitrating Regulatory T Cells by Cytokine and Programmed Cell Death 1-Containing Exosomes
por: Li, Peiyao, et al.
Publicado: (2017)

Serum Nardilysin as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma
por: Xu, Yongfeng, et al.
Publicado: (2022)

Expression of LRRC8A is elevated in the cytoplasm of osteosarcoma tissues: An immunohistochemical study with tissue microarrays
por: Zhang, Ningfeng, et al.
Publicado: (2021)

Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma
por: Ormanns, Steffen, et al.
Publicado: (2015)

Prognostic Biomarkers for Pancreatic Ductal Adenocarcinoma: An Umbrella Review
por: Wang, Yizhi, et al.
Publicado: (2020)

Potential prognostic biomarkers in pancreatic juice of resectable pancreatic ductal adenocarcinoma
por: Agrawal, Shefali
Publicado: (2017)

Three-lncRNA signature is a potential prognostic biomarker for pancreatic adenocarcinoma
por: Shi, Xiuhui, et al.
Publicado: (2018)

Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma
por: Alhasan, Sari F, et al.
Publicado: (2016)

Identification of EMT-Related lncRNAs as Potential Prognostic Biomarkers and Therapeutic Targets for Pancreatic Adenocarcinoma
por: Deng, Yanyao, et al.
Publicado: (2022)

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
por: Liu, Heng, et al.
Publicado: (2023)

Overexpression of LRRC59 Is Associated with Poor Prognosis and Promotes Cell Proliferation and Invasion in Lung Adenocarcinoma
por: Li, Dong, et al.
Publicado: (2020)

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function
por: Kumar, Lalit, et al.
Publicado: (2014)

The Application of [(68)Ga]-Labeled FAPI-04 PET/CT for Targeting and Early Detection of Pancreatic Carcinoma in Patient-Derived Orthotopic Xenograft Models
por: Zhang, He, et al.
Publicado: (2022)

Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma
por: Zhang, Zilong, et al.
Publicado: (2022)

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis
por: Wu, Geting, et al.
Publicado: (2021)

Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers
por: Shi, Yachen, et al.
Publicado: (2021)

Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
por: Yamada, Toshiki, et al.
Publicado: (2018)

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice
por: Lück, Jennifer C., et al.
Publicado: (2018)

Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
por: Friard, Jonas, et al.
Publicado: (2017)

Biophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels
por: König, Benjamin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_622n1t6chs1bs7kfpf1pjt5e7a