Label-Free Sensing of Biomolecular Adsorption and Desorption Dynamics by Interfacial Second Harmonic Generation

Observing interfacial molecular adsorption and desorption dynamics in a label-free manner is fundamentally important for understanding spatiotemporal transports of matter and energy across interfaces. Here, we report a label-free real-time sensing technique utilizing strong optical second harmonic g...

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Detalles Bibliográficos
Autores principales: Xia, Chuansheng, Sun, Jianli, Wang, Qiong, Chen, Jinping, Wang, Tianjie, Xu, Wenxiong, Zhang, He, Li, Yuanyuan, Chang, Jianhua, Shi, Zengliang, Xu, Chunxiang, Cui, Qiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688933/
https://www.ncbi.nlm.nih.gov/pubmed/36421166
http://dx.doi.org/10.3390/bios12111048
Descripción
Sumario:Observing interfacial molecular adsorption and desorption dynamics in a label-free manner is fundamentally important for understanding spatiotemporal transports of matter and energy across interfaces. Here, we report a label-free real-time sensing technique utilizing strong optical second harmonic generation of monolayer 2D semiconductors. BSA molecule adsorption and desorption dynamics on the surface of monolayer MoS(2) in liquid environments have been all-optically observed through time-resolved second harmonic generation (SHG) measurements. The proposed SHG detection scheme is not only interface specific but also expected to be widely applicable, which, in principle, undertakes a nanometer-scale spatial resolution across interfaces.

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