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Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells

Bone defects and fractures heal slowly compared with injuries to other tissues, creating a heavy burden for patients, their families, and society. Alongside conventional treatment methods for fractures and bone defects, adjuvant therapies play an important but underappreciated role. In a previous st...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Liu, Xuenan, Wei, Donghao, Zhu, Yuan, Wang, Feilong, Liu, Xuejiao, Yan, Fanyu, Zhang, Xiao, Liu, Yunsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688934/
https://www.ncbi.nlm.nih.gov/pubmed/36429048
http://dx.doi.org/10.3390/cells11223620
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author Yang, Fan
Liu, Xuenan
Wei, Donghao
Zhu, Yuan
Wang, Feilong
Liu, Xuejiao
Yan, Fanyu
Zhang, Xiao
Liu, Yunsong
author_facet Yang, Fan
Liu, Xuenan
Wei, Donghao
Zhu, Yuan
Wang, Feilong
Liu, Xuejiao
Yan, Fanyu
Zhang, Xiao
Liu, Yunsong
author_sort Yang, Fan
collection PubMed
description Bone defects and fractures heal slowly compared with injuries to other tissues, creating a heavy burden for patients, their families, and society. Alongside conventional treatment methods for fractures and bone defects, adjuvant therapies play an important but underappreciated role. In a previous study, we found that systemic administration of flufenamic acid promoted osteogenesis in vivo, but its side effects limited the application of our findings. In the present study, we assess the effects of external butyl flufenamate ointment on the healing of cranial defects in mice. We found that application of butyl flufenamate ointment on the surface of the skin accelerated the healing of cranial defects in mice by promoting BMP2 secretion from mouse-skin mesenchymal stem-cells. These findings indicate that butyl flufenamate ointment has potential therapeutic value for treating superficial fractures or bone defects while avoiding the toxicity and side effects of systemic medication, representing a safe and convenient adjuvant therapy to promote healing of superficial bone defects and fractures.
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spelling pubmed-96889342022-11-25 Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells Yang, Fan Liu, Xuenan Wei, Donghao Zhu, Yuan Wang, Feilong Liu, Xuejiao Yan, Fanyu Zhang, Xiao Liu, Yunsong Cells Article Bone defects and fractures heal slowly compared with injuries to other tissues, creating a heavy burden for patients, their families, and society. Alongside conventional treatment methods for fractures and bone defects, adjuvant therapies play an important but underappreciated role. In a previous study, we found that systemic administration of flufenamic acid promoted osteogenesis in vivo, but its side effects limited the application of our findings. In the present study, we assess the effects of external butyl flufenamate ointment on the healing of cranial defects in mice. We found that application of butyl flufenamate ointment on the surface of the skin accelerated the healing of cranial defects in mice by promoting BMP2 secretion from mouse-skin mesenchymal stem-cells. These findings indicate that butyl flufenamate ointment has potential therapeutic value for treating superficial fractures or bone defects while avoiding the toxicity and side effects of systemic medication, representing a safe and convenient adjuvant therapy to promote healing of superficial bone defects and fractures. MDPI 2022-11-15 /pmc/articles/PMC9688934/ /pubmed/36429048 http://dx.doi.org/10.3390/cells11223620 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Fan
Liu, Xuenan
Wei, Donghao
Zhu, Yuan
Wang, Feilong
Liu, Xuejiao
Yan, Fanyu
Zhang, Xiao
Liu, Yunsong
Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title_full Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title_fullStr Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title_full_unstemmed Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title_short Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells
title_sort topical application of butyl flufenamate ointment promotes cranial defect healing in mice by inducing bmp2 secretion in skin mesenchymal stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688934/
https://www.ncbi.nlm.nih.gov/pubmed/36429048
http://dx.doi.org/10.3390/cells11223620
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