Cargando…

A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease

Whether papillary carcinoma (PC) behavior is more aggressive in Graves’ disease (GD) patients than PC cases without GD is controversial. We retrospectively enrolled 33 thyroidectomized PC/GD patients during long-term follow-up, 23/33 without risk factors at surgery, and 18/33 microcarcinomas; 312 PC...

Descripción completa

Detalles Bibliográficos
Autores principales: Marongiu, Andrea, Nuvoli, Susanna, De Vito, Andrea, Rondini, Maria, Spanu, Angela, Madeddu, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689017/
https://www.ncbi.nlm.nih.gov/pubmed/36428861
http://dx.doi.org/10.3390/diagnostics12112801
_version_ 1784836416717455360
author Marongiu, Andrea
Nuvoli, Susanna
De Vito, Andrea
Rondini, Maria
Spanu, Angela
Madeddu, Giuseppe
author_facet Marongiu, Andrea
Nuvoli, Susanna
De Vito, Andrea
Rondini, Maria
Spanu, Angela
Madeddu, Giuseppe
author_sort Marongiu, Andrea
collection PubMed
description Whether papillary carcinoma (PC) behavior is more aggressive in Graves’ disease (GD) patients than PC cases without GD is controversial. We retrospectively enrolled 33 thyroidectomized PC/GD patients during long-term follow-up, 23/33 without risk factors at surgery, and 18/33 microcarcinomas; 312 PC euthyroid-matched patients without risk factors served as controls. A total of 14/33 (42.4%) PC/GD patients, 4 with and 10 without risk factors at diagnosis, 6 with microcarcinoma, underwent metastases during follow-up. In controls, metastases in 21/312 (6.7%) were ascertained. Considering 10/23 PC/GD patients and 21/312 controls without risk factors who developed metastases, univariate analysis showed that there was an increased risk of metastasis appearance for PC/GD cases (p < 0.001). Disease-free survival (DFS) was significantly (p < 0.0001, log-rank test) shorter in PC/GD patients than in controls. Significantly more elevated aggressiveness in 6/18 PC/GD patients with microcarcinoma than in controls was also ascertained with shorter DFS. Thus, in the present study, PC/GD had aggressive behavior during follow-up also when carcinoma characteristics were favorable and some cases were microcarcinomas. GD and non-GD patient comparison in the cases without risk factors at diagnosis showed an increased risk to develop metastases in GD during follow-up, suggesting that GD alone might be a tumor aggressiveness predictive factor in these cases.
format Online
Article
Text
id pubmed-9689017
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96890172022-11-25 A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease Marongiu, Andrea Nuvoli, Susanna De Vito, Andrea Rondini, Maria Spanu, Angela Madeddu, Giuseppe Diagnostics (Basel) Article Whether papillary carcinoma (PC) behavior is more aggressive in Graves’ disease (GD) patients than PC cases without GD is controversial. We retrospectively enrolled 33 thyroidectomized PC/GD patients during long-term follow-up, 23/33 without risk factors at surgery, and 18/33 microcarcinomas; 312 PC euthyroid-matched patients without risk factors served as controls. A total of 14/33 (42.4%) PC/GD patients, 4 with and 10 without risk factors at diagnosis, 6 with microcarcinoma, underwent metastases during follow-up. In controls, metastases in 21/312 (6.7%) were ascertained. Considering 10/23 PC/GD patients and 21/312 controls without risk factors who developed metastases, univariate analysis showed that there was an increased risk of metastasis appearance for PC/GD cases (p < 0.001). Disease-free survival (DFS) was significantly (p < 0.0001, log-rank test) shorter in PC/GD patients than in controls. Significantly more elevated aggressiveness in 6/18 PC/GD patients with microcarcinoma than in controls was also ascertained with shorter DFS. Thus, in the present study, PC/GD had aggressive behavior during follow-up also when carcinoma characteristics were favorable and some cases were microcarcinomas. GD and non-GD patient comparison in the cases without risk factors at diagnosis showed an increased risk to develop metastases in GD during follow-up, suggesting that GD alone might be a tumor aggressiveness predictive factor in these cases. MDPI 2022-11-15 /pmc/articles/PMC9689017/ /pubmed/36428861 http://dx.doi.org/10.3390/diagnostics12112801 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marongiu, Andrea
Nuvoli, Susanna
De Vito, Andrea
Rondini, Maria
Spanu, Angela
Madeddu, Giuseppe
A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title_full A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title_fullStr A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title_full_unstemmed A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title_short A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
title_sort comparative follow-up study of patients with papillary thyroid carcinoma associated or not with graves’ disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689017/
https://www.ncbi.nlm.nih.gov/pubmed/36428861
http://dx.doi.org/10.3390/diagnostics12112801
work_keys_str_mv AT marongiuandrea acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT nuvolisusanna acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT devitoandrea acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT rondinimaria acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT spanuangela acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT madeddugiuseppe acomparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT marongiuandrea comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT nuvolisusanna comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT devitoandrea comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT rondinimaria comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT spanuangela comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease
AT madeddugiuseppe comparativefollowupstudyofpatientswithpapillarythyroidcarcinomaassociatedornotwithgravesdisease