Cargando…
Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now?
Multiple Sclerosis (MS) is a chronic pathological condition representing one of the main causes of neurological disability in the female young population. MS, as an immune disorder, could impact fetus development, and, considering the need for and the possibility of pharmacological treatment during...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689039/ https://www.ncbi.nlm.nih.gov/pubmed/36360444 http://dx.doi.org/10.3390/children9111716 |
_version_ | 1784836423173537792 |
---|---|
author | Siracusano, Martina Carloni, Elisa Riccioni, Assia Ferrara, Marialaura Scoppola, Chiara Arturi, Lucrezia Niolu, Cinzia Marfia, Girolama Alessandra Mazzone, Luigi |
author_facet | Siracusano, Martina Carloni, Elisa Riccioni, Assia Ferrara, Marialaura Scoppola, Chiara Arturi, Lucrezia Niolu, Cinzia Marfia, Girolama Alessandra Mazzone, Luigi |
author_sort | Siracusano, Martina |
collection | PubMed |
description | Multiple Sclerosis (MS) is a chronic pathological condition representing one of the main causes of neurological disability in the female young population. MS, as an immune disorder, could impact fetus development, and, considering the need for and the possibility of pharmacological treatment during pregnancy, the possible influence of medication on developmental trajectories represents a topic of great interest. We provide an overview of the available literature on the influence of maternal Multiple Sclerosis on offspring cognitive and behavioral development. A study was conducted on Pubmed, Medline and Google Scholar, considering empirical studies and reviews exclusively in the English language. Maternal MS appears not to be associated with emotional and behavioral problems, as evaluated through retrospective studies. However, a specific cognitive and behavioral phenotype, through the administration of standardized instruments, has not been delineated yet. Available studies on the topic are characterized by poor methodology and do not lead to conclusions. This overview highlights implications for further longitudinal studies which should delineate offspring developmental trajectories, taking into consideration maternal confounding factors and the exposure to pharmacological treatment in pregnancy. |
format | Online Article Text |
id | pubmed-9689039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96890392022-11-25 Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? Siracusano, Martina Carloni, Elisa Riccioni, Assia Ferrara, Marialaura Scoppola, Chiara Arturi, Lucrezia Niolu, Cinzia Marfia, Girolama Alessandra Mazzone, Luigi Children (Basel) Review Multiple Sclerosis (MS) is a chronic pathological condition representing one of the main causes of neurological disability in the female young population. MS, as an immune disorder, could impact fetus development, and, considering the need for and the possibility of pharmacological treatment during pregnancy, the possible influence of medication on developmental trajectories represents a topic of great interest. We provide an overview of the available literature on the influence of maternal Multiple Sclerosis on offspring cognitive and behavioral development. A study was conducted on Pubmed, Medline and Google Scholar, considering empirical studies and reviews exclusively in the English language. Maternal MS appears not to be associated with emotional and behavioral problems, as evaluated through retrospective studies. However, a specific cognitive and behavioral phenotype, through the administration of standardized instruments, has not been delineated yet. Available studies on the topic are characterized by poor methodology and do not lead to conclusions. This overview highlights implications for further longitudinal studies which should delineate offspring developmental trajectories, taking into consideration maternal confounding factors and the exposure to pharmacological treatment in pregnancy. MDPI 2022-11-09 /pmc/articles/PMC9689039/ /pubmed/36360444 http://dx.doi.org/10.3390/children9111716 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Siracusano, Martina Carloni, Elisa Riccioni, Assia Ferrara, Marialaura Scoppola, Chiara Arturi, Lucrezia Niolu, Cinzia Marfia, Girolama Alessandra Mazzone, Luigi Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title | Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title_full | Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title_fullStr | Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title_full_unstemmed | Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title_short | Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now? |
title_sort | maternal multiple sclerosis and offspring’s cognitive and behavioral development: what do we know until now? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689039/ https://www.ncbi.nlm.nih.gov/pubmed/36360444 http://dx.doi.org/10.3390/children9111716 |
work_keys_str_mv | AT siracusanomartina maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT carlonielisa maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT riccioniassia maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT ferraramarialaura maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT scoppolachiara maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT arturilucrezia maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT niolucinzia maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT marfiagirolamaalessandra maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow AT mazzoneluigi maternalmultiplesclerosisandoffspringscognitiveandbehavioraldevelopmentwhatdoweknowuntilnow |