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Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery

Background: This paper’s intent is to describe the neonatal hemodynamic characteristics of recipient twins of monochorionic pregnancies complicated with twin-to-twin transfusion syndrome (TTTS), born without prenatal fetoscopic selective laser coagulation (FSLC). Methods: Retrospective analysis of h...

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Autores principales: Chambon, Edouard, Hachem, Taymme, Salvador, Elodie, Rigourd, Virginie, Bellanger, Claire, Stirnemann, Julien, Kermorvant-Duchemin, Elsa, Tissieres, Pierre, Ville, Yves, Lapillonne, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689049/
https://www.ncbi.nlm.nih.gov/pubmed/36421215
http://dx.doi.org/10.3390/children9111766
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author Chambon, Edouard
Hachem, Taymme
Salvador, Elodie
Rigourd, Virginie
Bellanger, Claire
Stirnemann, Julien
Kermorvant-Duchemin, Elsa
Tissieres, Pierre
Ville, Yves
Lapillonne, Alexandre
author_facet Chambon, Edouard
Hachem, Taymme
Salvador, Elodie
Rigourd, Virginie
Bellanger, Claire
Stirnemann, Julien
Kermorvant-Duchemin, Elsa
Tissieres, Pierre
Ville, Yves
Lapillonne, Alexandre
author_sort Chambon, Edouard
collection PubMed
description Background: This paper’s intent is to describe the neonatal hemodynamic characteristics of recipient twins of monochorionic pregnancies complicated with twin-to-twin transfusion syndrome (TTTS), born without prenatal fetoscopic selective laser coagulation (FSLC). Methods: Retrospective analysis of hemodynamic characteristics was performed during the first five days of life of recipient twins from untreated TTTS. Results: Forty-two recipient twins were included and divided into three groups: no hemodynamic impairment (NoHI) (n = 15, 36%), isolated high blood pressure (HighBP) (n = 12, 28%), and cardiac failure group (CF) (n = 15, 36%). Patients of both CF and HighBP groups had high systolic blood pressure during the first 12 h of life and ventricular hypertrophy at early echocardiography. Cardiac failure occurred at a median age of 14 h (IQR = 6–24) and was followed by a drop in systolic and diastolic blood pressure. Acute kidney injury was more frequent (93% vs. 25%, p < 0.001) and severe (p <0.001) in the CF group than in the HighBP group. The mortality rate in the CF group was 40%. Factors associated with CF were twin anemia-polycythemia sequence (p = 0.012), very preterm birth (p = 0.040), and polycythemia (p = 0.002). Conclusion: One-third of recipient twins born without prenatal FSLC developed life-threatening cardiac failure during the first 24 h of life.
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spelling pubmed-96890492022-11-25 Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery Chambon, Edouard Hachem, Taymme Salvador, Elodie Rigourd, Virginie Bellanger, Claire Stirnemann, Julien Kermorvant-Duchemin, Elsa Tissieres, Pierre Ville, Yves Lapillonne, Alexandre Children (Basel) Article Background: This paper’s intent is to describe the neonatal hemodynamic characteristics of recipient twins of monochorionic pregnancies complicated with twin-to-twin transfusion syndrome (TTTS), born without prenatal fetoscopic selective laser coagulation (FSLC). Methods: Retrospective analysis of hemodynamic characteristics was performed during the first five days of life of recipient twins from untreated TTTS. Results: Forty-two recipient twins were included and divided into three groups: no hemodynamic impairment (NoHI) (n = 15, 36%), isolated high blood pressure (HighBP) (n = 12, 28%), and cardiac failure group (CF) (n = 15, 36%). Patients of both CF and HighBP groups had high systolic blood pressure during the first 12 h of life and ventricular hypertrophy at early echocardiography. Cardiac failure occurred at a median age of 14 h (IQR = 6–24) and was followed by a drop in systolic and diastolic blood pressure. Acute kidney injury was more frequent (93% vs. 25%, p < 0.001) and severe (p <0.001) in the CF group than in the HighBP group. The mortality rate in the CF group was 40%. Factors associated with CF were twin anemia-polycythemia sequence (p = 0.012), very preterm birth (p = 0.040), and polycythemia (p = 0.002). Conclusion: One-third of recipient twins born without prenatal FSLC developed life-threatening cardiac failure during the first 24 h of life. MDPI 2022-11-17 /pmc/articles/PMC9689049/ /pubmed/36421215 http://dx.doi.org/10.3390/children9111766 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chambon, Edouard
Hachem, Taymme
Salvador, Elodie
Rigourd, Virginie
Bellanger, Claire
Stirnemann, Julien
Kermorvant-Duchemin, Elsa
Tissieres, Pierre
Ville, Yves
Lapillonne, Alexandre
Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title_full Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title_fullStr Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title_full_unstemmed Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title_short Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery
title_sort neonatal hemodynamic characteristics of the recipient twin of twin-to-twin transfusion syndrome not treated with fetoscopic laser surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689049/
https://www.ncbi.nlm.nih.gov/pubmed/36421215
http://dx.doi.org/10.3390/children9111766
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