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Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors

Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the...

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Autores principales: Mehkri, Yusuf, Woodford, Samuel, Pierre, Kevin, Dagra, Abeer, Hernandez, Jairo, Reza Hosseini Siyanaki, Mohammad, Azab, Mohammed, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689062/
https://www.ncbi.nlm.nih.gov/pubmed/36421349
http://dx.doi.org/10.3390/curroncol29110696
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author Mehkri, Yusuf
Woodford, Samuel
Pierre, Kevin
Dagra, Abeer
Hernandez, Jairo
Reza Hosseini Siyanaki, Mohammad
Azab, Mohammed
Lucke-Wold, Brandon
author_facet Mehkri, Yusuf
Woodford, Samuel
Pierre, Kevin
Dagra, Abeer
Hernandez, Jairo
Reza Hosseini Siyanaki, Mohammad
Azab, Mohammed
Lucke-Wold, Brandon
author_sort Mehkri, Yusuf
collection PubMed
description Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care.
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spelling pubmed-96890622022-11-25 Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors Mehkri, Yusuf Woodford, Samuel Pierre, Kevin Dagra, Abeer Hernandez, Jairo Reza Hosseini Siyanaki, Mohammad Azab, Mohammed Lucke-Wold, Brandon Curr Oncol Review Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care. MDPI 2022-11-17 /pmc/articles/PMC9689062/ /pubmed/36421349 http://dx.doi.org/10.3390/curroncol29110696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mehkri, Yusuf
Woodford, Samuel
Pierre, Kevin
Dagra, Abeer
Hernandez, Jairo
Reza Hosseini Siyanaki, Mohammad
Azab, Mohammed
Lucke-Wold, Brandon
Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title_full Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title_fullStr Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title_full_unstemmed Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title_short Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
title_sort focused delivery of chemotherapy to augment surgical management of brain tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689062/
https://www.ncbi.nlm.nih.gov/pubmed/36421349
http://dx.doi.org/10.3390/curroncol29110696
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