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Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery

In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray...

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Detalles Bibliográficos
Autores principales: Siles-Sánchez, María de las Nieves, Jaime, Laura, Villalva, Marisol, Santoyo, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689113/
https://www.ncbi.nlm.nih.gov/pubmed/36429249
http://dx.doi.org/10.3390/foods11223657
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author Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
author_facet Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
author_sort Siles-Sánchez, María de las Nieves
collection PubMed
description In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems.
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spelling pubmed-96891132022-11-25 Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery Siles-Sánchez, María de las Nieves Jaime, Laura Villalva, Marisol Santoyo, Susana Foods Article In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems. MDPI 2022-11-16 /pmc/articles/PMC9689113/ /pubmed/36429249 http://dx.doi.org/10.3390/foods11223657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title_full Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title_fullStr Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title_full_unstemmed Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title_short Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
title_sort encapsulation of marjoram phenolic compounds using chitosan to improve its colon delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689113/
https://www.ncbi.nlm.nih.gov/pubmed/36429249
http://dx.doi.org/10.3390/foods11223657
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