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Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation

Contrast-enhanced imaging for choroidal malignant melanoma (CMM) is mostly limited to detecting metastatic tumors, possibly due to difficulties in fixing the eye position. We aimed to (1) validate the appropriateness of estimating iodine concentration based on dual-energy computed tomography (DECT)...

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Autores principales: Tsuchiya, Hiroki, Tachibana, Yasuhiko, Kishimoto, Riwa, Omatsu, Tokuhiko, Hotta, Eika, Tanimoto, Katsuyuki, Wakatsuki, Masaru, Obata, Takayuki, Tsuji, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689166/
https://www.ncbi.nlm.nih.gov/pubmed/36359535
http://dx.doi.org/10.3390/diagnostics12112692
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author Tsuchiya, Hiroki
Tachibana, Yasuhiko
Kishimoto, Riwa
Omatsu, Tokuhiko
Hotta, Eika
Tanimoto, Katsuyuki
Wakatsuki, Masaru
Obata, Takayuki
Tsuji, Hiroshi
author_facet Tsuchiya, Hiroki
Tachibana, Yasuhiko
Kishimoto, Riwa
Omatsu, Tokuhiko
Hotta, Eika
Tanimoto, Katsuyuki
Wakatsuki, Masaru
Obata, Takayuki
Tsuji, Hiroshi
author_sort Tsuchiya, Hiroki
collection PubMed
description Contrast-enhanced imaging for choroidal malignant melanoma (CMM) is mostly limited to detecting metastatic tumors, possibly due to difficulties in fixing the eye position. We aimed to (1) validate the appropriateness of estimating iodine concentration based on dual-energy computed tomography (DECT) for CMM and optimize the calculation parameters for estimation, and (2) perform a primary clinical validation by assessing the ability of this technique to show changes in CMM after charged-particle radiation therapy. The accuracy of the optimized estimate (eIC_optimized) was compared to an estimate obtained by commercial software (eIC_commercial) by determining the difference from the ground truth. Then, eIC_optimized, tumor volume, and CT values (80 kVp, 140 kVp, and synthesized 120 kVp) were measured at pre-treatment and 3 months and 1.5–2 years after treatment. The difference from the ground truth was significantly smaller in eIC_optimized than in eIC_commercial (p < 0.01). Tumor volume, CT values, and eIC_optimized all decreased significantly at 1.5–2 years after treatment, but only eIC_commercial showed a significant reduction at 3 months after treatment (p < 0.01). eIC_optimized can quantify contrast enhancement in primary CMM lesions and has high sensitivity for detecting the response to charged-particle radiation therapy, making it potentially useful for treatment monitoring.
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spelling pubmed-96891662022-11-25 Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation Tsuchiya, Hiroki Tachibana, Yasuhiko Kishimoto, Riwa Omatsu, Tokuhiko Hotta, Eika Tanimoto, Katsuyuki Wakatsuki, Masaru Obata, Takayuki Tsuji, Hiroshi Diagnostics (Basel) Article Contrast-enhanced imaging for choroidal malignant melanoma (CMM) is mostly limited to detecting metastatic tumors, possibly due to difficulties in fixing the eye position. We aimed to (1) validate the appropriateness of estimating iodine concentration based on dual-energy computed tomography (DECT) for CMM and optimize the calculation parameters for estimation, and (2) perform a primary clinical validation by assessing the ability of this technique to show changes in CMM after charged-particle radiation therapy. The accuracy of the optimized estimate (eIC_optimized) was compared to an estimate obtained by commercial software (eIC_commercial) by determining the difference from the ground truth. Then, eIC_optimized, tumor volume, and CT values (80 kVp, 140 kVp, and synthesized 120 kVp) were measured at pre-treatment and 3 months and 1.5–2 years after treatment. The difference from the ground truth was significantly smaller in eIC_optimized than in eIC_commercial (p < 0.01). Tumor volume, CT values, and eIC_optimized all decreased significantly at 1.5–2 years after treatment, but only eIC_commercial showed a significant reduction at 3 months after treatment (p < 0.01). eIC_optimized can quantify contrast enhancement in primary CMM lesions and has high sensitivity for detecting the response to charged-particle radiation therapy, making it potentially useful for treatment monitoring. MDPI 2022-11-04 /pmc/articles/PMC9689166/ /pubmed/36359535 http://dx.doi.org/10.3390/diagnostics12112692 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsuchiya, Hiroki
Tachibana, Yasuhiko
Kishimoto, Riwa
Omatsu, Tokuhiko
Hotta, Eika
Tanimoto, Katsuyuki
Wakatsuki, Masaru
Obata, Takayuki
Tsuji, Hiroshi
Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title_full Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title_fullStr Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title_full_unstemmed Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title_short Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation
title_sort dual-energy computed tomography-based iodine concentration estimation for evaluating choroidal malignant melanoma response to treatment: optimization and primary validation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689166/
https://www.ncbi.nlm.nih.gov/pubmed/36359535
http://dx.doi.org/10.3390/diagnostics12112692
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