CD8 Encephalitis: A Diagnostic Dilemma

CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and ‘viral escape’ phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HI...

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Detalles Bibliográficos
Autores principales: Sharma, Rohan, Spradley, Thomas, Campbell, Morgan, Biyani, Shubham, Singhal, Pulkit, Elkhider, Hisham, Nalleballe, Krishna, Gokden, Murat, Kumar, Manoj, Kapoor, Nidhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689240/
https://www.ncbi.nlm.nih.gov/pubmed/36359530
http://dx.doi.org/10.3390/diagnostics12112687
Descripción
Sumario:CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and ‘viral escape’ phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HIV who developed CD8 encephalitis following Herpes simplex encephalitis. He had persistent encephalopathy for several weeks with status epilepticus and agitated delirium, and diagnosis remained elusive until a brain biopsy confirmed the diagnosis.

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