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Alternative RNA Conformations: Companion or Combatant

RNA molecules, in one form or another, are involved in almost all aspects of cell physiology, as well as in disease development. The diversity of the functional roles of RNA comes from its intrinsic ability to adopt complex secondary and tertiary structures, rivaling the diversity of proteins. The R...

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Autores principales: Gupta, Payal, Khadake, Rushikesh M., Panja, Shounok, Shinde, Krushna, Rode, Ambadas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689429/
https://www.ncbi.nlm.nih.gov/pubmed/36360167
http://dx.doi.org/10.3390/genes13111930
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author Gupta, Payal
Khadake, Rushikesh M.
Panja, Shounok
Shinde, Krushna
Rode, Ambadas B.
author_facet Gupta, Payal
Khadake, Rushikesh M.
Panja, Shounok
Shinde, Krushna
Rode, Ambadas B.
author_sort Gupta, Payal
collection PubMed
description RNA molecules, in one form or another, are involved in almost all aspects of cell physiology, as well as in disease development. The diversity of the functional roles of RNA comes from its intrinsic ability to adopt complex secondary and tertiary structures, rivaling the diversity of proteins. The RNA molecules form dynamic ensembles of many interconverting conformations at a timescale of seconds, which is a key for understanding how they execute their cellular functions. Given the crucial role of RNAs in various cellular processes, we need to understand the RNA molecules from a structural perspective. Central to this review are studies aimed at revealing the regulatory role of conformational equilibria in RNA in humans to understand genetic diseases such as cancer and neurodegenerative diseases, as well as in pathogens such as bacteria and viruses so as to understand the progression of infectious diseases. Furthermore, we also summarize the prior studies on the use of RNA structures as platforms for the rational design of small molecules for therapeutic applications.
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spelling pubmed-96894292022-11-25 Alternative RNA Conformations: Companion or Combatant Gupta, Payal Khadake, Rushikesh M. Panja, Shounok Shinde, Krushna Rode, Ambadas B. Genes (Basel) Review RNA molecules, in one form or another, are involved in almost all aspects of cell physiology, as well as in disease development. The diversity of the functional roles of RNA comes from its intrinsic ability to adopt complex secondary and tertiary structures, rivaling the diversity of proteins. The RNA molecules form dynamic ensembles of many interconverting conformations at a timescale of seconds, which is a key for understanding how they execute their cellular functions. Given the crucial role of RNAs in various cellular processes, we need to understand the RNA molecules from a structural perspective. Central to this review are studies aimed at revealing the regulatory role of conformational equilibria in RNA in humans to understand genetic diseases such as cancer and neurodegenerative diseases, as well as in pathogens such as bacteria and viruses so as to understand the progression of infectious diseases. Furthermore, we also summarize the prior studies on the use of RNA structures as platforms for the rational design of small molecules for therapeutic applications. MDPI 2022-10-23 /pmc/articles/PMC9689429/ /pubmed/36360167 http://dx.doi.org/10.3390/genes13111930 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gupta, Payal
Khadake, Rushikesh M.
Panja, Shounok
Shinde, Krushna
Rode, Ambadas B.
Alternative RNA Conformations: Companion or Combatant
title Alternative RNA Conformations: Companion or Combatant
title_full Alternative RNA Conformations: Companion or Combatant
title_fullStr Alternative RNA Conformations: Companion or Combatant
title_full_unstemmed Alternative RNA Conformations: Companion or Combatant
title_short Alternative RNA Conformations: Companion or Combatant
title_sort alternative rna conformations: companion or combatant
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689429/
https://www.ncbi.nlm.nih.gov/pubmed/36360167
http://dx.doi.org/10.3390/genes13111930
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