Cargando…
Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689519/ https://www.ncbi.nlm.nih.gov/pubmed/36421342 http://dx.doi.org/10.3390/curroncol29110689 |
_version_ | 1784836555500683264 |
---|---|
author | Cheng, Vicki Oveisi, Niki McTaggart-Cowan, Helen Loree, Jonathan M. Murphy, Rachel A. De Vera, Mary A. |
author_facet | Cheng, Vicki Oveisi, Niki McTaggart-Cowan, Helen Loree, Jonathan M. Murphy, Rachel A. De Vera, Mary A. |
author_sort | Cheng, Vicki |
collection | PubMed |
description | Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assessed depression only. Meta-analyses showed a non-significant association between CRC and anxiety (pooled HR 1.67; 95% CI 0.88 to 3.17) and a significant association between CRC and depression (pooled HR 1.78; 95% CI 1.23 to 2.57). Predictors of anxiety and depression among patients with CRC included clinical characteristics (e.g., comorbidities, cancer stage, cancer site), cancer treatment (e.g., radiotherapy, chemotherapy, colostomy), and sociodemographic characteristics (e.g., age, sex). The impacts of anxiety and depression in patients with CRC included increased mortality and decreased quality of life. Altogether, our systematic review and meta-analysis quantified the risks and impacts of CRC on anxiety and depression, particularly an increased risk of depression after CRC diagnosis. Findings provide support for oncologic care that encompasses mental health supports for patients with CRC. |
format | Online Article Text |
id | pubmed-9689519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96895192022-11-25 Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis Cheng, Vicki Oveisi, Niki McTaggart-Cowan, Helen Loree, Jonathan M. Murphy, Rachel A. De Vera, Mary A. Curr Oncol Systematic Review Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assessed depression only. Meta-analyses showed a non-significant association between CRC and anxiety (pooled HR 1.67; 95% CI 0.88 to 3.17) and a significant association between CRC and depression (pooled HR 1.78; 95% CI 1.23 to 2.57). Predictors of anxiety and depression among patients with CRC included clinical characteristics (e.g., comorbidities, cancer stage, cancer site), cancer treatment (e.g., radiotherapy, chemotherapy, colostomy), and sociodemographic characteristics (e.g., age, sex). The impacts of anxiety and depression in patients with CRC included increased mortality and decreased quality of life. Altogether, our systematic review and meta-analysis quantified the risks and impacts of CRC on anxiety and depression, particularly an increased risk of depression after CRC diagnosis. Findings provide support for oncologic care that encompasses mental health supports for patients with CRC. MDPI 2022-11-15 /pmc/articles/PMC9689519/ /pubmed/36421342 http://dx.doi.org/10.3390/curroncol29110689 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Cheng, Vicki Oveisi, Niki McTaggart-Cowan, Helen Loree, Jonathan M. Murphy, Rachel A. De Vera, Mary A. Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title | Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title_full | Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title_fullStr | Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title_short | Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis |
title_sort | colorectal cancer and onset of anxiety and depression: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689519/ https://www.ncbi.nlm.nih.gov/pubmed/36421342 http://dx.doi.org/10.3390/curroncol29110689 |
work_keys_str_mv | AT chengvicki colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis AT oveisiniki colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis AT mctaggartcowanhelen colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis AT loreejonathanm colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis AT murphyrachela colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis AT deveramarya colorectalcancerandonsetofanxietyanddepressionasystematicreviewandmetaanalysis |