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Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis

Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched...

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Autores principales: Cheng, Vicki, Oveisi, Niki, McTaggart-Cowan, Helen, Loree, Jonathan M., Murphy, Rachel A., De Vera, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689519/
https://www.ncbi.nlm.nih.gov/pubmed/36421342
http://dx.doi.org/10.3390/curroncol29110689
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author Cheng, Vicki
Oveisi, Niki
McTaggart-Cowan, Helen
Loree, Jonathan M.
Murphy, Rachel A.
De Vera, Mary A.
author_facet Cheng, Vicki
Oveisi, Niki
McTaggart-Cowan, Helen
Loree, Jonathan M.
Murphy, Rachel A.
De Vera, Mary A.
author_sort Cheng, Vicki
collection PubMed
description Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assessed depression only. Meta-analyses showed a non-significant association between CRC and anxiety (pooled HR 1.67; 95% CI 0.88 to 3.17) and a significant association between CRC and depression (pooled HR 1.78; 95% CI 1.23 to 2.57). Predictors of anxiety and depression among patients with CRC included clinical characteristics (e.g., comorbidities, cancer stage, cancer site), cancer treatment (e.g., radiotherapy, chemotherapy, colostomy), and sociodemographic characteristics (e.g., age, sex). The impacts of anxiety and depression in patients with CRC included increased mortality and decreased quality of life. Altogether, our systematic review and meta-analysis quantified the risks and impacts of CRC on anxiety and depression, particularly an increased risk of depression after CRC diagnosis. Findings provide support for oncologic care that encompasses mental health supports for patients with CRC.
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spelling pubmed-96895192022-11-25 Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis Cheng, Vicki Oveisi, Niki McTaggart-Cowan, Helen Loree, Jonathan M. Murphy, Rachel A. De Vera, Mary A. Curr Oncol Systematic Review Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assessed depression only. Meta-analyses showed a non-significant association between CRC and anxiety (pooled HR 1.67; 95% CI 0.88 to 3.17) and a significant association between CRC and depression (pooled HR 1.78; 95% CI 1.23 to 2.57). Predictors of anxiety and depression among patients with CRC included clinical characteristics (e.g., comorbidities, cancer stage, cancer site), cancer treatment (e.g., radiotherapy, chemotherapy, colostomy), and sociodemographic characteristics (e.g., age, sex). The impacts of anxiety and depression in patients with CRC included increased mortality and decreased quality of life. Altogether, our systematic review and meta-analysis quantified the risks and impacts of CRC on anxiety and depression, particularly an increased risk of depression after CRC diagnosis. Findings provide support for oncologic care that encompasses mental health supports for patients with CRC. MDPI 2022-11-15 /pmc/articles/PMC9689519/ /pubmed/36421342 http://dx.doi.org/10.3390/curroncol29110689 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Cheng, Vicki
Oveisi, Niki
McTaggart-Cowan, Helen
Loree, Jonathan M.
Murphy, Rachel A.
De Vera, Mary A.
Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title_full Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title_fullStr Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title_full_unstemmed Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title_short Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis
title_sort colorectal cancer and onset of anxiety and depression: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689519/
https://www.ncbi.nlm.nih.gov/pubmed/36421342
http://dx.doi.org/10.3390/curroncol29110689
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