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Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity

Objectives: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis with characteristic involvement of the spine and sacroiliac joints. MRI may be the only indicator of disease activity or response. This study aimed to use a novel water fraction measurement technique on MRI as a biomarker to...

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Autores principales: Kim, Beum Jin, Lee, Young Han, Lee, Joohee, Kim, Sungjun, Song, Ho-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689651/
https://www.ncbi.nlm.nih.gov/pubmed/36428906
http://dx.doi.org/10.3390/diagnostics12112842
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author Kim, Beum Jin
Lee, Young Han
Lee, Joohee
Kim, Sungjun
Song, Ho-Taek
author_facet Kim, Beum Jin
Lee, Young Han
Lee, Joohee
Kim, Sungjun
Song, Ho-Taek
author_sort Kim, Beum Jin
collection PubMed
description Objectives: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis with characteristic involvement of the spine and sacroiliac joints. MRI may be the only indicator of disease activity or response. This study aimed to use a novel water fraction measurement technique on MRI as a biomarker to predict disease activity in patients with AS. Methods: We enrolled 39 patients (18 men [mean age, 38.6 years; range, 18–59 years] and 21 women [mean age, 39.3 years; range, 23–61 years]) who were clinically diagnosed with AS and underwent MRI, including mDixon sequences. Water fraction values of sacroiliac joint subchondral bone marrow were derived from the mDixon sequences. The Ankylosing Spondylitis Disease Activity Score (ASDAS) was recorded using clinical information and laboratory values from medical records. Multiple linear regression, Firth logistic regression, and intraclass correlation coefficients were used for the statistical analysis. Results: In multiple linear regression, water fraction, subchondral bone marrow edema, subchondral bone erosion, and subchondral bone marrow enhancements were significantly associated with ASDAS with C-reactive protein (ASDAS-CRP). The water fraction parameters showed a good linear correlation with ASDAS-CRP and ASDAS with erythrocyte sedimentation rate (ASDAS-ESR) (beta coefficient = 1.98, p < 0.001 and beta coefficient = 1.60, p = 0.003). Firth logistic regression showed that water fraction was a significant predictor of ASDAS-CRP but not ASDAS-ESR. The intraclass correlation coefficient showed excellent repeatability for the three repeated measures of the water fraction. Conclusion: Water fraction parameter could be a good imaging biomarker of disease activity status. The sacroiliac joint evaluated by mDixon MRI may be a promising biomarker of disease progression in patients with spondyloarthritis.
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spelling pubmed-96896512022-11-25 Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity Kim, Beum Jin Lee, Young Han Lee, Joohee Kim, Sungjun Song, Ho-Taek Diagnostics (Basel) Article Objectives: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis with characteristic involvement of the spine and sacroiliac joints. MRI may be the only indicator of disease activity or response. This study aimed to use a novel water fraction measurement technique on MRI as a biomarker to predict disease activity in patients with AS. Methods: We enrolled 39 patients (18 men [mean age, 38.6 years; range, 18–59 years] and 21 women [mean age, 39.3 years; range, 23–61 years]) who were clinically diagnosed with AS and underwent MRI, including mDixon sequences. Water fraction values of sacroiliac joint subchondral bone marrow were derived from the mDixon sequences. The Ankylosing Spondylitis Disease Activity Score (ASDAS) was recorded using clinical information and laboratory values from medical records. Multiple linear regression, Firth logistic regression, and intraclass correlation coefficients were used for the statistical analysis. Results: In multiple linear regression, water fraction, subchondral bone marrow edema, subchondral bone erosion, and subchondral bone marrow enhancements were significantly associated with ASDAS with C-reactive protein (ASDAS-CRP). The water fraction parameters showed a good linear correlation with ASDAS-CRP and ASDAS with erythrocyte sedimentation rate (ASDAS-ESR) (beta coefficient = 1.98, p < 0.001 and beta coefficient = 1.60, p = 0.003). Firth logistic regression showed that water fraction was a significant predictor of ASDAS-CRP but not ASDAS-ESR. The intraclass correlation coefficient showed excellent repeatability for the three repeated measures of the water fraction. Conclusion: Water fraction parameter could be a good imaging biomarker of disease activity status. The sacroiliac joint evaluated by mDixon MRI may be a promising biomarker of disease progression in patients with spondyloarthritis. MDPI 2022-11-17 /pmc/articles/PMC9689651/ /pubmed/36428906 http://dx.doi.org/10.3390/diagnostics12112842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Beum Jin
Lee, Young Han
Lee, Joohee
Kim, Sungjun
Song, Ho-Taek
Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title_full Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title_fullStr Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title_full_unstemmed Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title_short Water Fraction Ratio of the Sacroiliac Joint Subchondral Bone Marrow in Patients with Ankylosing Spondylitis Predicts the Degree of Disease Activity
title_sort water fraction ratio of the sacroiliac joint subchondral bone marrow in patients with ankylosing spondylitis predicts the degree of disease activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689651/
https://www.ncbi.nlm.nih.gov/pubmed/36428906
http://dx.doi.org/10.3390/diagnostics12112842
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