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DNA Damage-Induced RNAPII Degradation and Its Consequences in Gene Expression

RPB1, the major and catalytic subunit of human RNA Polymerase II (RNAPII), is specifically degraded by the ubiquitin–proteasome system upon induction of DNA damage by different agents, such as ultraviolet (UV) light. The “last resort” model of RNAPII degradation states that a persistently stalled RN...

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Detalles Bibliográficos
Autores principales:	Muñoz, Juan Cristobal, Beckerman, Inés, Choudhary, Ramveer, Bouvier, León Alberto, Muñoz, Manuel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689695/ https://www.ncbi.nlm.nih.gov/pubmed/36360188 http://dx.doi.org/10.3390/genes13111951

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