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Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prep...

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Autores principales: Baron, Raluca Ioana, Duceac, Ioana A., Morariu, Simona, Bostănaru-Iliescu, Andra-Cristina, Coseri, Sergiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689722/
https://www.ncbi.nlm.nih.gov/pubmed/36354634
http://dx.doi.org/10.3390/gels8110726
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author Baron, Raluca Ioana
Duceac, Ioana A.
Morariu, Simona
Bostănaru-Iliescu, Andra-Cristina
Coseri, Sergiu
author_facet Baron, Raluca Ioana
Duceac, Ioana A.
Morariu, Simona
Bostănaru-Iliescu, Andra-Cristina
Coseri, Sergiu
author_sort Baron, Raluca Ioana
collection PubMed
description The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.
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spelling pubmed-96897222022-11-25 Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings Baron, Raluca Ioana Duceac, Ioana A. Morariu, Simona Bostănaru-Iliescu, Andra-Cristina Coseri, Sergiu Gels Article The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management. MDPI 2022-11-09 /pmc/articles/PMC9689722/ /pubmed/36354634 http://dx.doi.org/10.3390/gels8110726 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baron, Raluca Ioana
Duceac, Ioana A.
Morariu, Simona
Bostănaru-Iliescu, Andra-Cristina
Coseri, Sergiu
Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title_full Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title_fullStr Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title_full_unstemmed Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title_short Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
title_sort hemostatic cryogels based on oxidized pullulan/dopamine with potential use as wound dressings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689722/
https://www.ncbi.nlm.nih.gov/pubmed/36354634
http://dx.doi.org/10.3390/gels8110726
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