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Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prep...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689722/ https://www.ncbi.nlm.nih.gov/pubmed/36354634 http://dx.doi.org/10.3390/gels8110726 |
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author | Baron, Raluca Ioana Duceac, Ioana A. Morariu, Simona Bostănaru-Iliescu, Andra-Cristina Coseri, Sergiu |
author_facet | Baron, Raluca Ioana Duceac, Ioana A. Morariu, Simona Bostănaru-Iliescu, Andra-Cristina Coseri, Sergiu |
author_sort | Baron, Raluca Ioana |
collection | PubMed |
description | The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management. |
format | Online Article Text |
id | pubmed-9689722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96897222022-11-25 Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings Baron, Raluca Ioana Duceac, Ioana A. Morariu, Simona Bostănaru-Iliescu, Andra-Cristina Coseri, Sergiu Gels Article The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management. MDPI 2022-11-09 /pmc/articles/PMC9689722/ /pubmed/36354634 http://dx.doi.org/10.3390/gels8110726 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baron, Raluca Ioana Duceac, Ioana A. Morariu, Simona Bostănaru-Iliescu, Andra-Cristina Coseri, Sergiu Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title | Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title_full | Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title_fullStr | Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title_full_unstemmed | Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title_short | Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings |
title_sort | hemostatic cryogels based on oxidized pullulan/dopamine with potential use as wound dressings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689722/ https://www.ncbi.nlm.nih.gov/pubmed/36354634 http://dx.doi.org/10.3390/gels8110726 |
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