Cargando…

The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study

Background: Fat alterations are frequent in people with HIV (PWH) and predict worse cardiometabolic outcomes. Visceral adipose tissue (VAT) is associated with ectopic fat accumulation in the liver. We aimed to investigate nonalcoholic fatty liver disease (NAFLD) diagnosed by controlled attenuation p...

Descripción completa

Detalles Bibliográficos
Autores principales: Sebastiani, Giada, Paisible, Nathalie, Costiniuk, Cecilia, Cox, Joseph, Kablawi, Dana, Klein, Marina B., Kronfli, Nadine, Routy, Jean-Pierre, Falutz, Julian, Lebouché, Bertrand, Guaraldi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689790/
https://www.ncbi.nlm.nih.gov/pubmed/36359434
http://dx.doi.org/10.3390/diagnostics12112590
_version_ 1784836623030026240
author Sebastiani, Giada
Paisible, Nathalie
Costiniuk, Cecilia
Cox, Joseph
Kablawi, Dana
Klein, Marina B.
Kronfli, Nadine
Routy, Jean-Pierre
Falutz, Julian
Lebouché, Bertrand
Guaraldi, Giovanni
author_facet Sebastiani, Giada
Paisible, Nathalie
Costiniuk, Cecilia
Cox, Joseph
Kablawi, Dana
Klein, Marina B.
Kronfli, Nadine
Routy, Jean-Pierre
Falutz, Julian
Lebouché, Bertrand
Guaraldi, Giovanni
author_sort Sebastiani, Giada
collection PubMed
description Background: Fat alterations are frequent in people with HIV (PWH) and predict worse cardiometabolic outcomes. Visceral adipose tissue (VAT) is associated with ectopic fat accumulation in the liver. We aimed to investigate nonalcoholic fatty liver disease (NAFLD) diagnosed by controlled attenuation parameter (CAP) as a potential marker of visceral adiposity in PWH. Methods: We conducted a prospective pilot study of HIV mono-infected patients undergoing metabolic characterization and paired CAP measured by transient elastography with dual-energy X-ray absorptiometry (DEXA) scan. NAFLD was defined as CAP ≥ 285 dB/m, in absence of alcohol abuse. Excess visceral adiposity was defined as VAT > 1.32 Kg. Pairwise correlation, area under the curve (AUC) and logistic regression analysis were employed to study the association between VAT and CAP. Results: Thirty patients were included, of whom 50% had NAFLD. CAP was correlated with VAT (r = 0.650, p < 0.001) measured by DEXA scan. After adjusting for duration of HIV infection, body mass index and waist circumference, CAP remained the only independent predictor of excess VAT (adjusted odds ratio 1.05, 95% confidence interval [CI] 1.01–1.10). The AUC analysis determined CAP had excellent performance to diagnose excess VAT (AUC 0.92, 95% CI 0.81–1.00), higher than BMI and waist circumference. The optimized CAP cut-off to diagnose excess VAT was 266 dB/m, with a sensitivity of 88.3% and a specificity of 84.6%. Conclusions: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine.
format Online
Article
Text
id pubmed-9689790
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96897902022-11-25 The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study Sebastiani, Giada Paisible, Nathalie Costiniuk, Cecilia Cox, Joseph Kablawi, Dana Klein, Marina B. Kronfli, Nadine Routy, Jean-Pierre Falutz, Julian Lebouché, Bertrand Guaraldi, Giovanni Diagnostics (Basel) Brief Report Background: Fat alterations are frequent in people with HIV (PWH) and predict worse cardiometabolic outcomes. Visceral adipose tissue (VAT) is associated with ectopic fat accumulation in the liver. We aimed to investigate nonalcoholic fatty liver disease (NAFLD) diagnosed by controlled attenuation parameter (CAP) as a potential marker of visceral adiposity in PWH. Methods: We conducted a prospective pilot study of HIV mono-infected patients undergoing metabolic characterization and paired CAP measured by transient elastography with dual-energy X-ray absorptiometry (DEXA) scan. NAFLD was defined as CAP ≥ 285 dB/m, in absence of alcohol abuse. Excess visceral adiposity was defined as VAT > 1.32 Kg. Pairwise correlation, area under the curve (AUC) and logistic regression analysis were employed to study the association between VAT and CAP. Results: Thirty patients were included, of whom 50% had NAFLD. CAP was correlated with VAT (r = 0.650, p < 0.001) measured by DEXA scan. After adjusting for duration of HIV infection, body mass index and waist circumference, CAP remained the only independent predictor of excess VAT (adjusted odds ratio 1.05, 95% confidence interval [CI] 1.01–1.10). The AUC analysis determined CAP had excellent performance to diagnose excess VAT (AUC 0.92, 95% CI 0.81–1.00), higher than BMI and waist circumference. The optimized CAP cut-off to diagnose excess VAT was 266 dB/m, with a sensitivity of 88.3% and a specificity of 84.6%. Conclusions: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine. MDPI 2022-10-26 /pmc/articles/PMC9689790/ /pubmed/36359434 http://dx.doi.org/10.3390/diagnostics12112590 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Sebastiani, Giada
Paisible, Nathalie
Costiniuk, Cecilia
Cox, Joseph
Kablawi, Dana
Klein, Marina B.
Kronfli, Nadine
Routy, Jean-Pierre
Falutz, Julian
Lebouché, Bertrand
Guaraldi, Giovanni
The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title_full The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title_fullStr The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title_full_unstemmed The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title_short The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study
title_sort relationship between visceral adiposity and nonalcoholic fatty liver disease diagnosed by controlled attenuation parameter in people with hiv: a pilot study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689790/
https://www.ncbi.nlm.nih.gov/pubmed/36359434
http://dx.doi.org/10.3390/diagnostics12112590
work_keys_str_mv AT sebastianigiada therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT paisiblenathalie therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT costiniukcecilia therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT coxjoseph therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kablawidana therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kleinmarinab therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kronflinadine therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT routyjeanpierre therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT falutzjulian therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT lebouchebertrand therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT guaraldigiovanni therelationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT sebastianigiada relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT paisiblenathalie relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT costiniukcecilia relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT coxjoseph relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kablawidana relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kleinmarinab relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT kronflinadine relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT routyjeanpierre relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT falutzjulian relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT lebouchebertrand relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy
AT guaraldigiovanni relationshipbetweenvisceraladiposityandnonalcoholicfattyliverdiseasediagnosedbycontrolledattenuationparameterinpeoplewithhivapilotstudy