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Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast ti...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689826/ https://www.ncbi.nlm.nih.gov/pubmed/36421341 http://dx.doi.org/10.3390/curroncol29110688 |
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author | Rusnak, Alison Morrison, Shawna Smith, Erika Hastings, Valerie Anderson, Kelly Aldridge, Caitlin Zelenietz, Sari Reddick, Karen Regnier, Sonia Alie, Ellen Islam, Nayaar Fasih, Rutaaba Peddle, Susan Cordeiro, Erin Tomiak, Eva Seely, Jean M. |
author_facet | Rusnak, Alison Morrison, Shawna Smith, Erika Hastings, Valerie Anderson, Kelly Aldridge, Caitlin Zelenietz, Sari Reddick, Karen Regnier, Sonia Alie, Ellen Islam, Nayaar Fasih, Rutaaba Peddle, Susan Cordeiro, Erin Tomiak, Eva Seely, Jean M. |
author_sort | Rusnak, Alison |
collection | PubMed |
description | Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast tissue density (BTD) into the risk assessment of women referred to HROBSP who were not genetic mutation carriers. All consecutive women aged 40–69 years who met criteria for HROBSP assessment and referred to Genetics from 1 December 2020 to 31 July 2021 had their lifetime risk calculated with and without BTD using Tyrer-Cuzick model version 8 (IBISv8) to gauge overall impact. McNemar’s test was performed to compare eligibility with and without density. 140 women were referred, and 1 was excluded (BRCA gene mutation carrier and automatically eligible). Eight of 139 (5.8%) never had a mammogram, while 17/131 (13%) did not have BTD reported on their mammogram and required radiologist review. Of 131 patients, 22 (16.8%) were clinically impacted by incorporation of BTD: 9/131 (6.9%) became eligible for HROBSP, while 13/131 (9.9%) became ineligible (p = 0.394). It was feasible for the Genetics clinic to incorporate BTD for better risk stratification of eligible women. This did not significantly impact the number of eligible women while optimizing the use of high-risk supplemental MRI screening. |
format | Online Article Text |
id | pubmed-9689826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96898262022-11-25 Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment Rusnak, Alison Morrison, Shawna Smith, Erika Hastings, Valerie Anderson, Kelly Aldridge, Caitlin Zelenietz, Sari Reddick, Karen Regnier, Sonia Alie, Ellen Islam, Nayaar Fasih, Rutaaba Peddle, Susan Cordeiro, Erin Tomiak, Eva Seely, Jean M. Curr Oncol Article Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast tissue density (BTD) into the risk assessment of women referred to HROBSP who were not genetic mutation carriers. All consecutive women aged 40–69 years who met criteria for HROBSP assessment and referred to Genetics from 1 December 2020 to 31 July 2021 had their lifetime risk calculated with and without BTD using Tyrer-Cuzick model version 8 (IBISv8) to gauge overall impact. McNemar’s test was performed to compare eligibility with and without density. 140 women were referred, and 1 was excluded (BRCA gene mutation carrier and automatically eligible). Eight of 139 (5.8%) never had a mammogram, while 17/131 (13%) did not have BTD reported on their mammogram and required radiologist review. Of 131 patients, 22 (16.8%) were clinically impacted by incorporation of BTD: 9/131 (6.9%) became eligible for HROBSP, while 13/131 (9.9%) became ineligible (p = 0.394). It was feasible for the Genetics clinic to incorporate BTD for better risk stratification of eligible women. This did not significantly impact the number of eligible women while optimizing the use of high-risk supplemental MRI screening. MDPI 2022-11-15 /pmc/articles/PMC9689826/ /pubmed/36421341 http://dx.doi.org/10.3390/curroncol29110688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rusnak, Alison Morrison, Shawna Smith, Erika Hastings, Valerie Anderson, Kelly Aldridge, Caitlin Zelenietz, Sari Reddick, Karen Regnier, Sonia Alie, Ellen Islam, Nayaar Fasih, Rutaaba Peddle, Susan Cordeiro, Erin Tomiak, Eva Seely, Jean M. Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title | Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title_full | Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title_fullStr | Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title_full_unstemmed | Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title_short | Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment |
title_sort | feasibility study and clinical impact of incorporating breast tissue density in high-risk breast cancer screening assessment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689826/ https://www.ncbi.nlm.nih.gov/pubmed/36421341 http://dx.doi.org/10.3390/curroncol29110688 |
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