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Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment

Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast ti...

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Autores principales: Rusnak, Alison, Morrison, Shawna, Smith, Erika, Hastings, Valerie, Anderson, Kelly, Aldridge, Caitlin, Zelenietz, Sari, Reddick, Karen, Regnier, Sonia, Alie, Ellen, Islam, Nayaar, Fasih, Rutaaba, Peddle, Susan, Cordeiro, Erin, Tomiak, Eva, Seely, Jean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689826/
https://www.ncbi.nlm.nih.gov/pubmed/36421341
http://dx.doi.org/10.3390/curroncol29110688
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author Rusnak, Alison
Morrison, Shawna
Smith, Erika
Hastings, Valerie
Anderson, Kelly
Aldridge, Caitlin
Zelenietz, Sari
Reddick, Karen
Regnier, Sonia
Alie, Ellen
Islam, Nayaar
Fasih, Rutaaba
Peddle, Susan
Cordeiro, Erin
Tomiak, Eva
Seely, Jean M.
author_facet Rusnak, Alison
Morrison, Shawna
Smith, Erika
Hastings, Valerie
Anderson, Kelly
Aldridge, Caitlin
Zelenietz, Sari
Reddick, Karen
Regnier, Sonia
Alie, Ellen
Islam, Nayaar
Fasih, Rutaaba
Peddle, Susan
Cordeiro, Erin
Tomiak, Eva
Seely, Jean M.
author_sort Rusnak, Alison
collection PubMed
description Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast tissue density (BTD) into the risk assessment of women referred to HROBSP who were not genetic mutation carriers. All consecutive women aged 40–69 years who met criteria for HROBSP assessment and referred to Genetics from 1 December 2020 to 31 July 2021 had their lifetime risk calculated with and without BTD using Tyrer-Cuzick model version 8 (IBISv8) to gauge overall impact. McNemar’s test was performed to compare eligibility with and without density. 140 women were referred, and 1 was excluded (BRCA gene mutation carrier and automatically eligible). Eight of 139 (5.8%) never had a mammogram, while 17/131 (13%) did not have BTD reported on their mammogram and required radiologist review. Of 131 patients, 22 (16.8%) were clinically impacted by incorporation of BTD: 9/131 (6.9%) became eligible for HROBSP, while 13/131 (9.9%) became ineligible (p = 0.394). It was feasible for the Genetics clinic to incorporate BTD for better risk stratification of eligible women. This did not significantly impact the number of eligible women while optimizing the use of high-risk supplemental MRI screening.
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spelling pubmed-96898262022-11-25 Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment Rusnak, Alison Morrison, Shawna Smith, Erika Hastings, Valerie Anderson, Kelly Aldridge, Caitlin Zelenietz, Sari Reddick, Karen Regnier, Sonia Alie, Ellen Islam, Nayaar Fasih, Rutaaba Peddle, Susan Cordeiro, Erin Tomiak, Eva Seely, Jean M. Curr Oncol Article Breast tissue density (BTD) is known to increase the risk of breast cancer but is not routinely used in the risk assessment of the population-based High-Risk Ontario Breast Screening Program (HROBSP). This prospective, IRB-approved study assessed the feasibility and impact of incorporating breast tissue density (BTD) into the risk assessment of women referred to HROBSP who were not genetic mutation carriers. All consecutive women aged 40–69 years who met criteria for HROBSP assessment and referred to Genetics from 1 December 2020 to 31 July 2021 had their lifetime risk calculated with and without BTD using Tyrer-Cuzick model version 8 (IBISv8) to gauge overall impact. McNemar’s test was performed to compare eligibility with and without density. 140 women were referred, and 1 was excluded (BRCA gene mutation carrier and automatically eligible). Eight of 139 (5.8%) never had a mammogram, while 17/131 (13%) did not have BTD reported on their mammogram and required radiologist review. Of 131 patients, 22 (16.8%) were clinically impacted by incorporation of BTD: 9/131 (6.9%) became eligible for HROBSP, while 13/131 (9.9%) became ineligible (p = 0.394). It was feasible for the Genetics clinic to incorporate BTD for better risk stratification of eligible women. This did not significantly impact the number of eligible women while optimizing the use of high-risk supplemental MRI screening. MDPI 2022-11-15 /pmc/articles/PMC9689826/ /pubmed/36421341 http://dx.doi.org/10.3390/curroncol29110688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rusnak, Alison
Morrison, Shawna
Smith, Erika
Hastings, Valerie
Anderson, Kelly
Aldridge, Caitlin
Zelenietz, Sari
Reddick, Karen
Regnier, Sonia
Alie, Ellen
Islam, Nayaar
Fasih, Rutaaba
Peddle, Susan
Cordeiro, Erin
Tomiak, Eva
Seely, Jean M.
Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title_full Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title_fullStr Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title_full_unstemmed Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title_short Feasibility Study and Clinical Impact of Incorporating Breast Tissue Density in High-Risk Breast Cancer Screening Assessment
title_sort feasibility study and clinical impact of incorporating breast tissue density in high-risk breast cancer screening assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689826/
https://www.ncbi.nlm.nih.gov/pubmed/36421341
http://dx.doi.org/10.3390/curroncol29110688
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