A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder

Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a pre...

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Autores principales: Iwasa, Yuhei, Iwata, Keisuke, Okuno, Mitsuru, Sugiyama, Akihiko, Nishigaki, Yoichi, Ohashi, Yosuke, Tanaka, Takuji, Iwashita, Takuji, Shimizu, Masahito, Tomita, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689884/
https://www.ncbi.nlm.nih.gov/pubmed/36359563
http://dx.doi.org/10.3390/diagnostics12112721
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author Iwasa, Yuhei
Iwata, Keisuke
Okuno, Mitsuru
Sugiyama, Akihiko
Nishigaki, Yoichi
Ohashi, Yosuke
Tanaka, Takuji
Iwashita, Takuji
Shimizu, Masahito
Tomita, Eiichi
author_facet Iwasa, Yuhei
Iwata, Keisuke
Okuno, Mitsuru
Sugiyama, Akihiko
Nishigaki, Yoichi
Ohashi, Yosuke
Tanaka, Takuji
Iwashita, Takuji
Shimizu, Masahito
Tomita, Eiichi
author_sort Iwasa, Yuhei
collection PubMed
description Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a precancerous lesion of gallbladder cancer, there are some reports of cases of gallbladder cancer from ADM. Therefore, the relationship between ADM and gallbladder cancer remains controversial. We herein report a case of early-stage gallbladder cancer, BilIN3 (high grade), arising from ADM that was positive for ALDH1A1, an important marker of stem cells and cancer stem cells.
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spelling pubmed-96898842022-11-25 A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder Iwasa, Yuhei Iwata, Keisuke Okuno, Mitsuru Sugiyama, Akihiko Nishigaki, Yoichi Ohashi, Yosuke Tanaka, Takuji Iwashita, Takuji Shimizu, Masahito Tomita, Eiichi Diagnostics (Basel) Case Report Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a precancerous lesion of gallbladder cancer, there are some reports of cases of gallbladder cancer from ADM. Therefore, the relationship between ADM and gallbladder cancer remains controversial. We herein report a case of early-stage gallbladder cancer, BilIN3 (high grade), arising from ADM that was positive for ALDH1A1, an important marker of stem cells and cancer stem cells. MDPI 2022-11-07 /pmc/articles/PMC9689884/ /pubmed/36359563 http://dx.doi.org/10.3390/diagnostics12112721 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Iwasa, Yuhei
Iwata, Keisuke
Okuno, Mitsuru
Sugiyama, Akihiko
Nishigaki, Yoichi
Ohashi, Yosuke
Tanaka, Takuji
Iwashita, Takuji
Shimizu, Masahito
Tomita, Eiichi
A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title_full A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title_fullStr A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title_full_unstemmed A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title_short A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
title_sort case of early-stage gallbladder cancer, positive for aldh1a1, which arose from adenomyomatosis of the gallbladder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689884/
https://www.ncbi.nlm.nih.gov/pubmed/36359563
http://dx.doi.org/10.3390/diagnostics12112721
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