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Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review

Objective: The likelihood of timely treatment for cervical cancer increases with timely detection of abnormal cervical cells. Automated methods of detecting abnormal cervical cells were established because manual identification requires skilled pathologists and is time consuming and prone to error....

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Autores principales: Allahqoli, Leila, Laganà, Antonio Simone, Mazidimoradi, Afrooz, Salehiniya, Hamid, Günther, Veronika, Chiantera, Vito, Karimi Goghari, Shirin, Ghiasvand, Mohammad Matin, Rahmani, Azam, Momenimovahed, Zohre, Alkatout, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689914/
https://www.ncbi.nlm.nih.gov/pubmed/36428831
http://dx.doi.org/10.3390/diagnostics12112771
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author Allahqoli, Leila
Laganà, Antonio Simone
Mazidimoradi, Afrooz
Salehiniya, Hamid
Günther, Veronika
Chiantera, Vito
Karimi Goghari, Shirin
Ghiasvand, Mohammad Matin
Rahmani, Azam
Momenimovahed, Zohre
Alkatout, Ibrahim
author_facet Allahqoli, Leila
Laganà, Antonio Simone
Mazidimoradi, Afrooz
Salehiniya, Hamid
Günther, Veronika
Chiantera, Vito
Karimi Goghari, Shirin
Ghiasvand, Mohammad Matin
Rahmani, Azam
Momenimovahed, Zohre
Alkatout, Ibrahim
author_sort Allahqoli, Leila
collection PubMed
description Objective: The likelihood of timely treatment for cervical cancer increases with timely detection of abnormal cervical cells. Automated methods of detecting abnormal cervical cells were established because manual identification requires skilled pathologists and is time consuming and prone to error. The purpose of this systematic review is to evaluate the diagnostic performance of artificial intelligence (AI) technologies for the prediction, screening, and diagnosis of cervical cancer and pre-cancerous lesions. Materials and Methods: Comprehensive searches were performed on three databases: Medline, Web of Science Core Collection (Indexes = SCI-EXPANDED, SSCI, A & HCI Timespan) and Scopus to find papers published until July 2022. Articles that applied any AI technique for the prediction, screening, and diagnosis of cervical cancer were included in the review. No time restriction was applied. Articles were searched, screened, incorporated, and analyzed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results: The primary search yielded 2538 articles. After screening and evaluation of eligibility, 117 studies were incorporated in the review. AI techniques were found to play a significant role in screening systems for pre-cancerous and cancerous cervical lesions. The accuracy of the algorithms in predicting cervical cancer varied from 70% to 100%. AI techniques make a distinction between cancerous and normal Pap smears with 80–100% accuracy. AI is expected to serve as a practical tool for doctors in making accurate clinical diagnoses. The reported sensitivity and specificity of AI in colposcopy for the detection of CIN2+ were 71.9–98.22% and 51.8–96.2%, respectively. Conclusion: The present review highlights the acceptable performance of AI systems in the prediction, screening, or detection of cervical cancer and pre-cancerous lesions, especially when faced with a paucity of specialized centers or medical resources. In combination with human evaluation, AI could serve as a helpful tool in the interpretation of cervical smears or images.
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spelling pubmed-96899142022-11-25 Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review Allahqoli, Leila Laganà, Antonio Simone Mazidimoradi, Afrooz Salehiniya, Hamid Günther, Veronika Chiantera, Vito Karimi Goghari, Shirin Ghiasvand, Mohammad Matin Rahmani, Azam Momenimovahed, Zohre Alkatout, Ibrahim Diagnostics (Basel) Systematic Review Objective: The likelihood of timely treatment for cervical cancer increases with timely detection of abnormal cervical cells. Automated methods of detecting abnormal cervical cells were established because manual identification requires skilled pathologists and is time consuming and prone to error. The purpose of this systematic review is to evaluate the diagnostic performance of artificial intelligence (AI) technologies for the prediction, screening, and diagnosis of cervical cancer and pre-cancerous lesions. Materials and Methods: Comprehensive searches were performed on three databases: Medline, Web of Science Core Collection (Indexes = SCI-EXPANDED, SSCI, A & HCI Timespan) and Scopus to find papers published until July 2022. Articles that applied any AI technique for the prediction, screening, and diagnosis of cervical cancer were included in the review. No time restriction was applied. Articles were searched, screened, incorporated, and analyzed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results: The primary search yielded 2538 articles. After screening and evaluation of eligibility, 117 studies were incorporated in the review. AI techniques were found to play a significant role in screening systems for pre-cancerous and cancerous cervical lesions. The accuracy of the algorithms in predicting cervical cancer varied from 70% to 100%. AI techniques make a distinction between cancerous and normal Pap smears with 80–100% accuracy. AI is expected to serve as a practical tool for doctors in making accurate clinical diagnoses. The reported sensitivity and specificity of AI in colposcopy for the detection of CIN2+ were 71.9–98.22% and 51.8–96.2%, respectively. Conclusion: The present review highlights the acceptable performance of AI systems in the prediction, screening, or detection of cervical cancer and pre-cancerous lesions, especially when faced with a paucity of specialized centers or medical resources. In combination with human evaluation, AI could serve as a helpful tool in the interpretation of cervical smears or images. MDPI 2022-11-13 /pmc/articles/PMC9689914/ /pubmed/36428831 http://dx.doi.org/10.3390/diagnostics12112771 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Allahqoli, Leila
Laganà, Antonio Simone
Mazidimoradi, Afrooz
Salehiniya, Hamid
Günther, Veronika
Chiantera, Vito
Karimi Goghari, Shirin
Ghiasvand, Mohammad Matin
Rahmani, Azam
Momenimovahed, Zohre
Alkatout, Ibrahim
Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title_full Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title_fullStr Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title_full_unstemmed Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title_short Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review
title_sort diagnosis of cervical cancer and pre-cancerous lesions by artificial intelligence: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689914/
https://www.ncbi.nlm.nih.gov/pubmed/36428831
http://dx.doi.org/10.3390/diagnostics12112771
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