Cargando…

The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis

Medulloblastoma (MB) is considered the most common and highly malignant posterior fossa tumor (PFT) in children. The accurate preoperative diagnosis of MB is beneficial in choosing the appropriate surgical methods and treatment strategies. Diffusion-weighted imaging (DWI) has improved the accuracy o...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yi, Zhang, Siqi, Tan, Weiting, Lin, Guisen, Zhuang, Yijiang, Zeng, Hongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689934/
https://www.ncbi.nlm.nih.gov/pubmed/36428860
http://dx.doi.org/10.3390/diagnostics12112796
_version_ 1784836660131790848
author Luo, Yi
Zhang, Siqi
Tan, Weiting
Lin, Guisen
Zhuang, Yijiang
Zeng, Hongwu
author_facet Luo, Yi
Zhang, Siqi
Tan, Weiting
Lin, Guisen
Zhuang, Yijiang
Zeng, Hongwu
author_sort Luo, Yi
collection PubMed
description Medulloblastoma (MB) is considered the most common and highly malignant posterior fossa tumor (PFT) in children. The accurate preoperative diagnosis of MB is beneficial in choosing the appropriate surgical methods and treatment strategies. Diffusion-weighted imaging (DWI) has improved the accuracy of differential diagnosis of posterior fossa tumors. Nonetheless, further studies are needed to confirm its value for clinical application. This study aimed to evaluate the performance of DWI in differentiating MB from other PFT. A literature search was conducted using databases PubMed, Embase, and Web of Science for studies reporting the diagnostic performance of DWI for PFT from January 2000 to January 2022. A bivariate random-effects model was employed to evaluate the pooled sensitivities and specificities. A univariable meta-regression analysis was used to assess relevant factors for heterogeneity, and subgroup analyses were performed. A total of 15 studies with 823 patients were eligible for data extraction. Overall pooled sensitivity and specificity of DWI were 0.94 (95% confident interval [CI]: 0.89–0.97) and 0.94 (95% CI: 0.90–0.96) respectively. The area under the curve (AUC) of DWI was 0.98 (95% CI: 0.96–0.99). Heterogeneity was found in the sensitivity (I(2) = 62.59%) and the specificity (I(2) = 35.94%). Magnetic field intensity, region of interest definition and DWI diagnostic parameters are the factors that affect the diagnostic performance of DWI. DWI has excellent diagnostic accuracy for differentiating MB from other PFT. Hence, it is necessary to set DWI as a routine examination sequence for posterior fossa tumors.
format Online
Article
Text
id pubmed-9689934
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96899342022-11-25 The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis Luo, Yi Zhang, Siqi Tan, Weiting Lin, Guisen Zhuang, Yijiang Zeng, Hongwu Diagnostics (Basel) Systematic Review Medulloblastoma (MB) is considered the most common and highly malignant posterior fossa tumor (PFT) in children. The accurate preoperative diagnosis of MB is beneficial in choosing the appropriate surgical methods and treatment strategies. Diffusion-weighted imaging (DWI) has improved the accuracy of differential diagnosis of posterior fossa tumors. Nonetheless, further studies are needed to confirm its value for clinical application. This study aimed to evaluate the performance of DWI in differentiating MB from other PFT. A literature search was conducted using databases PubMed, Embase, and Web of Science for studies reporting the diagnostic performance of DWI for PFT from January 2000 to January 2022. A bivariate random-effects model was employed to evaluate the pooled sensitivities and specificities. A univariable meta-regression analysis was used to assess relevant factors for heterogeneity, and subgroup analyses were performed. A total of 15 studies with 823 patients were eligible for data extraction. Overall pooled sensitivity and specificity of DWI were 0.94 (95% confident interval [CI]: 0.89–0.97) and 0.94 (95% CI: 0.90–0.96) respectively. The area under the curve (AUC) of DWI was 0.98 (95% CI: 0.96–0.99). Heterogeneity was found in the sensitivity (I(2) = 62.59%) and the specificity (I(2) = 35.94%). Magnetic field intensity, region of interest definition and DWI diagnostic parameters are the factors that affect the diagnostic performance of DWI. DWI has excellent diagnostic accuracy for differentiating MB from other PFT. Hence, it is necessary to set DWI as a routine examination sequence for posterior fossa tumors. MDPI 2022-11-15 /pmc/articles/PMC9689934/ /pubmed/36428860 http://dx.doi.org/10.3390/diagnostics12112796 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Luo, Yi
Zhang, Siqi
Tan, Weiting
Lin, Guisen
Zhuang, Yijiang
Zeng, Hongwu
The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title_full The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title_fullStr The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title_full_unstemmed The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title_short The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis
title_sort diagnostic efficiency of quantitative diffusion weighted imaging in differentiating medulloblastoma from posterior fossa tumors: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689934/
https://www.ncbi.nlm.nih.gov/pubmed/36428860
http://dx.doi.org/10.3390/diagnostics12112796
work_keys_str_mv AT luoyi thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zhangsiqi thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT tanweiting thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT linguisen thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zhuangyijiang thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zenghongwu thediagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT luoyi diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zhangsiqi diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT tanweiting diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT linguisen diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zhuangyijiang diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis
AT zenghongwu diagnosticefficiencyofquantitativediffusionweightedimagingindifferentiatingmedulloblastomafromposteriorfossatumorsasystematicreviewandmetaanalysis