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The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis

We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases aga...

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Autores principales: Kriķe, Petra, Shums, Zakera, Poļaka, Inese, Kikuste, Ilze, Vanags, Aigars, Tolmanis, Ivars, Isajevs, Sergejs, Liepniece-Karele, Inta, Santare, Daiga, Tzivian, Lilian, Rudzīte, Dace, Song, Minkyo, Camargo, M. Constanza, Norman, Gary L., Leja, Mārcis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689963/
https://www.ncbi.nlm.nih.gov/pubmed/36428844
http://dx.doi.org/10.3390/diagnostics12112784
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author Kriķe, Petra
Shums, Zakera
Poļaka, Inese
Kikuste, Ilze
Vanags, Aigars
Tolmanis, Ivars
Isajevs, Sergejs
Liepniece-Karele, Inta
Santare, Daiga
Tzivian, Lilian
Rudzīte, Dace
Song, Minkyo
Camargo, M. Constanza
Norman, Gary L.
Leja, Mārcis
author_facet Kriķe, Petra
Shums, Zakera
Poļaka, Inese
Kikuste, Ilze
Vanags, Aigars
Tolmanis, Ivars
Isajevs, Sergejs
Liepniece-Karele, Inta
Santare, Daiga
Tzivian, Lilian
Rudzīte, Dace
Song, Minkyo
Camargo, M. Constanza
Norman, Gary L.
Leja, Mārcis
author_sort Kriķe, Petra
collection PubMed
description We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application.
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spelling pubmed-96899632022-11-25 The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis Kriķe, Petra Shums, Zakera Poļaka, Inese Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Isajevs, Sergejs Liepniece-Karele, Inta Santare, Daiga Tzivian, Lilian Rudzīte, Dace Song, Minkyo Camargo, M. Constanza Norman, Gary L. Leja, Mārcis Diagnostics (Basel) Article We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application. MDPI 2022-11-14 /pmc/articles/PMC9689963/ /pubmed/36428844 http://dx.doi.org/10.3390/diagnostics12112784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kriķe, Petra
Shums, Zakera
Poļaka, Inese
Kikuste, Ilze
Vanags, Aigars
Tolmanis, Ivars
Isajevs, Sergejs
Liepniece-Karele, Inta
Santare, Daiga
Tzivian, Lilian
Rudzīte, Dace
Song, Minkyo
Camargo, M. Constanza
Norman, Gary L.
Leja, Mārcis
The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title_full The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title_fullStr The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title_full_unstemmed The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title_short The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
title_sort diagnostic value of anti-parietal cell and intrinsic factor antibodies, pepsinogens, and gastrin-17 in corpus-restricted atrophic gastritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689963/
https://www.ncbi.nlm.nih.gov/pubmed/36428844
http://dx.doi.org/10.3390/diagnostics12112784
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