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The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases aga...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689963/ https://www.ncbi.nlm.nih.gov/pubmed/36428844 http://dx.doi.org/10.3390/diagnostics12112784 |
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author | Kriķe, Petra Shums, Zakera Poļaka, Inese Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Isajevs, Sergejs Liepniece-Karele, Inta Santare, Daiga Tzivian, Lilian Rudzīte, Dace Song, Minkyo Camargo, M. Constanza Norman, Gary L. Leja, Mārcis |
author_facet | Kriķe, Petra Shums, Zakera Poļaka, Inese Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Isajevs, Sergejs Liepniece-Karele, Inta Santare, Daiga Tzivian, Lilian Rudzīte, Dace Song, Minkyo Camargo, M. Constanza Norman, Gary L. Leja, Mārcis |
author_sort | Kriķe, Petra |
collection | PubMed |
description | We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application. |
format | Online Article Text |
id | pubmed-9689963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96899632022-11-25 The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis Kriķe, Petra Shums, Zakera Poļaka, Inese Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Isajevs, Sergejs Liepniece-Karele, Inta Santare, Daiga Tzivian, Lilian Rudzīte, Dace Song, Minkyo Camargo, M. Constanza Norman, Gary L. Leja, Mārcis Diagnostics (Basel) Article We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application. MDPI 2022-11-14 /pmc/articles/PMC9689963/ /pubmed/36428844 http://dx.doi.org/10.3390/diagnostics12112784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kriķe, Petra Shums, Zakera Poļaka, Inese Kikuste, Ilze Vanags, Aigars Tolmanis, Ivars Isajevs, Sergejs Liepniece-Karele, Inta Santare, Daiga Tzivian, Lilian Rudzīte, Dace Song, Minkyo Camargo, M. Constanza Norman, Gary L. Leja, Mārcis The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title | The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title_full | The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title_fullStr | The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title_full_unstemmed | The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title_short | The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis |
title_sort | diagnostic value of anti-parietal cell and intrinsic factor antibodies, pepsinogens, and gastrin-17 in corpus-restricted atrophic gastritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689963/ https://www.ncbi.nlm.nih.gov/pubmed/36428844 http://dx.doi.org/10.3390/diagnostics12112784 |
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