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Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity

Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with se...

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Autores principales: Abdallah, Marwa H., Elghamry, Hanaa A., Khalifa, Nasrin E., Khojali, Weam M. A., Khafagy, El-Sayed, Lila, Amr S. Abu, El-Horany, Hemat El-Sayed, El-Housiny, Shaimaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689995/
https://www.ncbi.nlm.nih.gov/pubmed/36421559
http://dx.doi.org/10.3390/gels8110737
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author Abdallah, Marwa H.
Elghamry, Hanaa A.
Khalifa, Nasrin E.
Khojali, Weam M. A.
Khafagy, El-Sayed
Lila, Amr S. Abu
El-Horany, Hemat El-Sayed
El-Housiny, Shaimaa
author_facet Abdallah, Marwa H.
Elghamry, Hanaa A.
Khalifa, Nasrin E.
Khojali, Weam M. A.
Khafagy, El-Sayed
Lila, Amr S. Abu
El-Horany, Hemat El-Sayed
El-Housiny, Shaimaa
author_sort Abdallah, Marwa H.
collection PubMed
description Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hind paw was employed to estimate the in vivo anti-inflammatory activity. The generated ginger extract formulations showed good viscosity and particle size. The in vitro release of ginger extract from niosomal formulation surpassed other formulations. In addition, the niosomal emulgel formulation showed improved transdermal flux and increased drug permeability through rabbit skin compared to other preparations. Most importantly, carrageenan-induced rat hind paw edema test confirmed the potential anti-inflammatory efficacy of ginger extract niosomal emulgel, compared to other formulations, as manifested by a significant decrease in paw edema with a superior edema inhibition potency. Overall, our findings suggest that incorporating a niosomal formulation within sesame oil-based emulgel might represent a plausible strategy for effective transdermal delivery of anti-inflammatory drugs like ginger extract.
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spelling pubmed-96899952022-11-25 Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity Abdallah, Marwa H. Elghamry, Hanaa A. Khalifa, Nasrin E. Khojali, Weam M. A. Khafagy, El-Sayed Lila, Amr S. Abu El-Horany, Hemat El-Sayed El-Housiny, Shaimaa Gels Article Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hind paw was employed to estimate the in vivo anti-inflammatory activity. The generated ginger extract formulations showed good viscosity and particle size. The in vitro release of ginger extract from niosomal formulation surpassed other formulations. In addition, the niosomal emulgel formulation showed improved transdermal flux and increased drug permeability through rabbit skin compared to other preparations. Most importantly, carrageenan-induced rat hind paw edema test confirmed the potential anti-inflammatory efficacy of ginger extract niosomal emulgel, compared to other formulations, as manifested by a significant decrease in paw edema with a superior edema inhibition potency. Overall, our findings suggest that incorporating a niosomal formulation within sesame oil-based emulgel might represent a plausible strategy for effective transdermal delivery of anti-inflammatory drugs like ginger extract. MDPI 2022-11-14 /pmc/articles/PMC9689995/ /pubmed/36421559 http://dx.doi.org/10.3390/gels8110737 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdallah, Marwa H.
Elghamry, Hanaa A.
Khalifa, Nasrin E.
Khojali, Weam M. A.
Khafagy, El-Sayed
Lila, Amr S. Abu
El-Horany, Hemat El-Sayed
El-Housiny, Shaimaa
Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title_full Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title_fullStr Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title_full_unstemmed Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title_short Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
title_sort ginger extract-loaded sesame oil-based niosomal emulgel: quality by design to ameliorate anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689995/
https://www.ncbi.nlm.nih.gov/pubmed/36421559
http://dx.doi.org/10.3390/gels8110737
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