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Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease

Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in ce...

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Autores principales: Pellegrini, Miguel, Bergonzoni, Guendalina, Perrone, Federica, Squitieri, Ferdinando, Biagioli, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689996/
https://www.ncbi.nlm.nih.gov/pubmed/36360254
http://dx.doi.org/10.3390/genes13112017
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author Pellegrini, Miguel
Bergonzoni, Guendalina
Perrone, Federica
Squitieri, Ferdinando
Biagioli, Marta
author_facet Pellegrini, Miguel
Bergonzoni, Guendalina
Perrone, Federica
Squitieri, Ferdinando
Biagioli, Marta
author_sort Pellegrini, Miguel
collection PubMed
description Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in cellular pathways, RNAs are also currently evaluated as possible disease biomarkers. They could be informative not only to follow disease progression and assess treatment efficacy in clinics, but also to aid in the development of new therapeutic approaches. This is especially important for neurological and genetic disorders, where the administration of appropriate treatment during the disease prodromal stage could significantly delay, if not halt, disease progression. In this review we focus on the current status of biomarkers in Huntington’s Disease (HD), a fatal hereditary and degenerative disease condition. First, we revise the sources and type of wet biomarkers currently in use. Then, we explore the feasibility of different RNA types (miRNA, ncRNA, circRNA) as possible biomarker candidates, discussing potential advantages, disadvantages, sources of origin and the ongoing investigations on this topic.
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spelling pubmed-96899962022-11-25 Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease Pellegrini, Miguel Bergonzoni, Guendalina Perrone, Federica Squitieri, Ferdinando Biagioli, Marta Genes (Basel) Review Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in cellular pathways, RNAs are also currently evaluated as possible disease biomarkers. They could be informative not only to follow disease progression and assess treatment efficacy in clinics, but also to aid in the development of new therapeutic approaches. This is especially important for neurological and genetic disorders, where the administration of appropriate treatment during the disease prodromal stage could significantly delay, if not halt, disease progression. In this review we focus on the current status of biomarkers in Huntington’s Disease (HD), a fatal hereditary and degenerative disease condition. First, we revise the sources and type of wet biomarkers currently in use. Then, we explore the feasibility of different RNA types (miRNA, ncRNA, circRNA) as possible biomarker candidates, discussing potential advantages, disadvantages, sources of origin and the ongoing investigations on this topic. MDPI 2022-11-03 /pmc/articles/PMC9689996/ /pubmed/36360254 http://dx.doi.org/10.3390/genes13112017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pellegrini, Miguel
Bergonzoni, Guendalina
Perrone, Federica
Squitieri, Ferdinando
Biagioli, Marta
Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title_full Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title_fullStr Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title_full_unstemmed Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title_short Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
title_sort current diagnostic methods and non-coding rnas as possible biomarkers in huntington’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689996/
https://www.ncbi.nlm.nih.gov/pubmed/36360254
http://dx.doi.org/10.3390/genes13112017
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