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Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease
Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in ce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689996/ https://www.ncbi.nlm.nih.gov/pubmed/36360254 http://dx.doi.org/10.3390/genes13112017 |
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author | Pellegrini, Miguel Bergonzoni, Guendalina Perrone, Federica Squitieri, Ferdinando Biagioli, Marta |
author_facet | Pellegrini, Miguel Bergonzoni, Guendalina Perrone, Federica Squitieri, Ferdinando Biagioli, Marta |
author_sort | Pellegrini, Miguel |
collection | PubMed |
description | Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in cellular pathways, RNAs are also currently evaluated as possible disease biomarkers. They could be informative not only to follow disease progression and assess treatment efficacy in clinics, but also to aid in the development of new therapeutic approaches. This is especially important for neurological and genetic disorders, where the administration of appropriate treatment during the disease prodromal stage could significantly delay, if not halt, disease progression. In this review we focus on the current status of biomarkers in Huntington’s Disease (HD), a fatal hereditary and degenerative disease condition. First, we revise the sources and type of wet biomarkers currently in use. Then, we explore the feasibility of different RNA types (miRNA, ncRNA, circRNA) as possible biomarker candidates, discussing potential advantages, disadvantages, sources of origin and the ongoing investigations on this topic. |
format | Online Article Text |
id | pubmed-9689996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96899962022-11-25 Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease Pellegrini, Miguel Bergonzoni, Guendalina Perrone, Federica Squitieri, Ferdinando Biagioli, Marta Genes (Basel) Review Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in cellular pathways, RNAs are also currently evaluated as possible disease biomarkers. They could be informative not only to follow disease progression and assess treatment efficacy in clinics, but also to aid in the development of new therapeutic approaches. This is especially important for neurological and genetic disorders, where the administration of appropriate treatment during the disease prodromal stage could significantly delay, if not halt, disease progression. In this review we focus on the current status of biomarkers in Huntington’s Disease (HD), a fatal hereditary and degenerative disease condition. First, we revise the sources and type of wet biomarkers currently in use. Then, we explore the feasibility of different RNA types (miRNA, ncRNA, circRNA) as possible biomarker candidates, discussing potential advantages, disadvantages, sources of origin and the ongoing investigations on this topic. MDPI 2022-11-03 /pmc/articles/PMC9689996/ /pubmed/36360254 http://dx.doi.org/10.3390/genes13112017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pellegrini, Miguel Bergonzoni, Guendalina Perrone, Federica Squitieri, Ferdinando Biagioli, Marta Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title | Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title_full | Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title_fullStr | Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title_full_unstemmed | Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title_short | Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease |
title_sort | current diagnostic methods and non-coding rnas as possible biomarkers in huntington’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689996/ https://www.ncbi.nlm.nih.gov/pubmed/36360254 http://dx.doi.org/10.3390/genes13112017 |
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