Cargando…

Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse

The mitochondrion was characterized for years as the energy factory of the cell, but now its role in many more cellular processes is recognized. The mitochondrion and mitochondrial DNA (mtDNA) also possess a set of distinct properties, including maternal inheritance, that creates the Mother’s Curse...

Descripción completa

Detalles Bibliográficos
Autores principales: Kyrgiafini, Maria-Anna, Giannoulis, Themistoklis, Moutou, Katerina A., Mamuris, Zissis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690142/
https://www.ncbi.nlm.nih.gov/pubmed/36421825
http://dx.doi.org/10.3390/genes13112151
_version_ 1784836712838463488
author Kyrgiafini, Maria-Anna
Giannoulis, Themistoklis
Moutou, Katerina A.
Mamuris, Zissis
author_facet Kyrgiafini, Maria-Anna
Giannoulis, Themistoklis
Moutou, Katerina A.
Mamuris, Zissis
author_sort Kyrgiafini, Maria-Anna
collection PubMed
description The mitochondrion was characterized for years as the energy factory of the cell, but now its role in many more cellular processes is recognized. The mitochondrion and mitochondrial DNA (mtDNA) also possess a set of distinct properties, including maternal inheritance, that creates the Mother’s Curse phenomenon. As mtDNA is inherited from females to all offspring, mutations that are harmful to males tend to accumulate more easily. The Mother’s Curse is associated with various diseases, and has a significant effect on males, in many cases even affecting their reproductive ability. Sometimes, it even leads to reproductive isolation, as in crosses between different populations, the mitochondrial genome cannot cooperate effectively with the nuclear one resulting in a mito-nuclear incompatibility and reduce the fitness of the hybrids. This phenomenon is observed both in the laboratory and in natural populations, and have the potential to influence their evolution and speciation. Therefore, it turns out that the study of mitochondria is an exciting field that finds many applications, including pest control, and it can shed light on the molecular mechanism of several diseases, improving successful diagnosis and therapeutics. Finally, mito-nuclear co-adaptation, paternal leakage, and kin selection are some mechanisms that can mitigate the impact of the Mother’s Curse.
format Online
Article
Text
id pubmed-9690142
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96901422022-11-25 Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse Kyrgiafini, Maria-Anna Giannoulis, Themistoklis Moutou, Katerina A. Mamuris, Zissis Genes (Basel) Review The mitochondrion was characterized for years as the energy factory of the cell, but now its role in many more cellular processes is recognized. The mitochondrion and mitochondrial DNA (mtDNA) also possess a set of distinct properties, including maternal inheritance, that creates the Mother’s Curse phenomenon. As mtDNA is inherited from females to all offspring, mutations that are harmful to males tend to accumulate more easily. The Mother’s Curse is associated with various diseases, and has a significant effect on males, in many cases even affecting their reproductive ability. Sometimes, it even leads to reproductive isolation, as in crosses between different populations, the mitochondrial genome cannot cooperate effectively with the nuclear one resulting in a mito-nuclear incompatibility and reduce the fitness of the hybrids. This phenomenon is observed both in the laboratory and in natural populations, and have the potential to influence their evolution and speciation. Therefore, it turns out that the study of mitochondria is an exciting field that finds many applications, including pest control, and it can shed light on the molecular mechanism of several diseases, improving successful diagnosis and therapeutics. Finally, mito-nuclear co-adaptation, paternal leakage, and kin selection are some mechanisms that can mitigate the impact of the Mother’s Curse. MDPI 2022-11-18 /pmc/articles/PMC9690142/ /pubmed/36421825 http://dx.doi.org/10.3390/genes13112151 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kyrgiafini, Maria-Anna
Giannoulis, Themistoklis
Moutou, Katerina A.
Mamuris, Zissis
Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title_full Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title_fullStr Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title_full_unstemmed Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title_short Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother’s Curse
title_sort investigating the impact of a curse: diseases, population isolation, evolution and the mother’s curse
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690142/
https://www.ncbi.nlm.nih.gov/pubmed/36421825
http://dx.doi.org/10.3390/genes13112151
work_keys_str_mv AT kyrgiafinimariaanna investigatingtheimpactofacursediseasespopulationisolationevolutionandthemotherscurse
AT giannoulisthemistoklis investigatingtheimpactofacursediseasespopulationisolationevolutionandthemotherscurse
AT moutoukaterinaa investigatingtheimpactofacursediseasespopulationisolationevolutionandthemotherscurse
AT mamuriszissis investigatingtheimpactofacursediseasespopulationisolationevolutionandthemotherscurse