Small Non-Coding RNAs in Human Cancer

Small non-coding RNAs are widespread in the biological world and have been extensively explored over the past decades. Their fundamental roles in human health and disease are increasingly appreciated. Furthermore, a growing number of studies have investigated the functions of small non-coding RNAs i...

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Detalles Bibliográficos
Autores principales: Xiong, Qunli, Zhang, Yaguang, Li, Junjun, Zhu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690286/
https://www.ncbi.nlm.nih.gov/pubmed/36360311
http://dx.doi.org/10.3390/genes13112072
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author Xiong, Qunli
Zhang, Yaguang
Li, Junjun
Zhu, Qing
author_facet Xiong, Qunli
Zhang, Yaguang
Li, Junjun
Zhu, Qing
author_sort Xiong, Qunli
collection PubMed
description Small non-coding RNAs are widespread in the biological world and have been extensively explored over the past decades. Their fundamental roles in human health and disease are increasingly appreciated. Furthermore, a growing number of studies have investigated the functions of small non-coding RNAs in cancer initiation and progression. In this review, we provide an overview of the biogenesis of small non-coding RNAs with a focus on microRNAs, PIWI-interacting RNAs, and a new class of tRNA-derived small RNAs. We discuss their biological functions in human cancer and highlight their clinical application as molecular biomarkers or therapeutic targets.
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spelling pubmed-96902862022-11-25 Small Non-Coding RNAs in Human Cancer Xiong, Qunli Zhang, Yaguang Li, Junjun Zhu, Qing Genes (Basel) Review Small non-coding RNAs are widespread in the biological world and have been extensively explored over the past decades. Their fundamental roles in human health and disease are increasingly appreciated. Furthermore, a growing number of studies have investigated the functions of small non-coding RNAs in cancer initiation and progression. In this review, we provide an overview of the biogenesis of small non-coding RNAs with a focus on microRNAs, PIWI-interacting RNAs, and a new class of tRNA-derived small RNAs. We discuss their biological functions in human cancer and highlight their clinical application as molecular biomarkers or therapeutic targets. MDPI 2022-11-09 /pmc/articles/PMC9690286/ /pubmed/36360311 http://dx.doi.org/10.3390/genes13112072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xiong, Qunli
Zhang, Yaguang
Li, Junjun
Zhu, Qing
Small Non-Coding RNAs in Human Cancer
title Small Non-Coding RNAs in Human Cancer
title_full Small Non-Coding RNAs in Human Cancer
title_fullStr Small Non-Coding RNAs in Human Cancer
title_full_unstemmed Small Non-Coding RNAs in Human Cancer
title_short Small Non-Coding RNAs in Human Cancer
title_sort small non-coding rnas in human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690286/
https://www.ncbi.nlm.nih.gov/pubmed/36360311
http://dx.doi.org/10.3390/genes13112072
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