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Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report

Background: Uganda ranks among the countries with the highest burden of TB the world and tuberculous pericarditis (TBP) affects up to 2% of people diagnosed with pulmonary tuberculosis worldwide. In Africa, it represents the most common cause of pericardial disease. Here, we present the case of a 21...

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Autores principales: De Vita, Elda, Segala, Francesco Vladimiro, Amone, James, Samuel, Kabuga, Marotta, Claudia, Putoto, Giovanni, Nassali, Ritah, Lochoro, Peter, Bavaro, Davide Fiore, Ictho, Jerry, Okori, Samuel, Di Gennaro, Francesco, Saracino, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690455/
https://www.ncbi.nlm.nih.gov/pubmed/36429861
http://dx.doi.org/10.3390/ijerph192215143
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author De Vita, Elda
Segala, Francesco Vladimiro
Amone, James
Samuel, Kabuga
Marotta, Claudia
Putoto, Giovanni
Nassali, Ritah
Lochoro, Peter
Bavaro, Davide Fiore
Ictho, Jerry
Okori, Samuel
Di Gennaro, Francesco
Saracino, Annalisa
author_facet De Vita, Elda
Segala, Francesco Vladimiro
Amone, James
Samuel, Kabuga
Marotta, Claudia
Putoto, Giovanni
Nassali, Ritah
Lochoro, Peter
Bavaro, Davide Fiore
Ictho, Jerry
Okori, Samuel
Di Gennaro, Francesco
Saracino, Annalisa
author_sort De Vita, Elda
collection PubMed
description Background: Uganda ranks among the countries with the highest burden of TB the world and tuberculous pericarditis (TBP) affects up to 2% of people diagnosed with pulmonary tuberculosis worldwide. In Africa, it represents the most common cause of pericardial disease. Here, we present the case of a 21-year-old male patient who was diagnosed of cardiac tamponade due to tuberculous pericarditis with a positive urine LF-LAM. Case report: We report a case of a 21-year-old male living in Oyam district, Uganda, who presented to the emergency department with difficulty in breathing, easy fatigability, general body weakness, and abdominal pain. A chest X-ray showed the presence of right pleural effusion and massive cardiomegaly. Thus, percutaneous pericardiocentesis was performed immediately and pericardial fluid resulted negative both for gram staining and real-time PCR test Xpert MTB/RIF. The following day’s urine LF-LAM test resulted positive, and antitubercular therapy started with gradual improvement. During the follow-up visits, the patient remained asymptomatic, reporting good compliance to the antitubercular therapy. Conclusion: Our case highlights the potential usefulness of a LF-LAM-based diagnostic approach, suggesting that, in low-resource settings, this test might be used as part of routine diagnostic workup in patients with pericardial disease or suspected extra-pulmonary tuberculosis.
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spelling pubmed-96904552022-11-25 Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report De Vita, Elda Segala, Francesco Vladimiro Amone, James Samuel, Kabuga Marotta, Claudia Putoto, Giovanni Nassali, Ritah Lochoro, Peter Bavaro, Davide Fiore Ictho, Jerry Okori, Samuel Di Gennaro, Francesco Saracino, Annalisa Int J Environ Res Public Health Case Report Background: Uganda ranks among the countries with the highest burden of TB the world and tuberculous pericarditis (TBP) affects up to 2% of people diagnosed with pulmonary tuberculosis worldwide. In Africa, it represents the most common cause of pericardial disease. Here, we present the case of a 21-year-old male patient who was diagnosed of cardiac tamponade due to tuberculous pericarditis with a positive urine LF-LAM. Case report: We report a case of a 21-year-old male living in Oyam district, Uganda, who presented to the emergency department with difficulty in breathing, easy fatigability, general body weakness, and abdominal pain. A chest X-ray showed the presence of right pleural effusion and massive cardiomegaly. Thus, percutaneous pericardiocentesis was performed immediately and pericardial fluid resulted negative both for gram staining and real-time PCR test Xpert MTB/RIF. The following day’s urine LF-LAM test resulted positive, and antitubercular therapy started with gradual improvement. During the follow-up visits, the patient remained asymptomatic, reporting good compliance to the antitubercular therapy. Conclusion: Our case highlights the potential usefulness of a LF-LAM-based diagnostic approach, suggesting that, in low-resource settings, this test might be used as part of routine diagnostic workup in patients with pericardial disease or suspected extra-pulmonary tuberculosis. MDPI 2022-11-17 /pmc/articles/PMC9690455/ /pubmed/36429861 http://dx.doi.org/10.3390/ijerph192215143 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
De Vita, Elda
Segala, Francesco Vladimiro
Amone, James
Samuel, Kabuga
Marotta, Claudia
Putoto, Giovanni
Nassali, Ritah
Lochoro, Peter
Bavaro, Davide Fiore
Ictho, Jerry
Okori, Samuel
Di Gennaro, Francesco
Saracino, Annalisa
Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title_full Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title_fullStr Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title_full_unstemmed Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title_short Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report
title_sort subacute cardiac tamponade due to tuberculous pericarditis diagnosed by urine lipoarabinomannan assay in a immunocompetent patient in oyam district, uganda: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690455/
https://www.ncbi.nlm.nih.gov/pubmed/36429861
http://dx.doi.org/10.3390/ijerph192215143
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