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Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease
Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple mechanisms such as alterations in lipid metaboli...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690481/ https://www.ncbi.nlm.nih.gov/pubmed/36421817 http://dx.doi.org/10.3390/genes13112142 |
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author | Ramos-Lopez, Omar |
author_facet | Ramos-Lopez, Omar |
author_sort | Ramos-Lopez, Omar |
collection | PubMed |
description | Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. However, the onset and progression of MAFLD is variable among individuals, being influenced by intrinsic (personal) and external environmental factors. In this context, sequence structural variants across the human genome, epigenetic phenomena (i.e., DNA methylation, histone modifications, and long non-coding RNAs) affecting gene expression, gut microbiota dysbiosis, and metabolomics/lipidomic fingerprints may account for differences in MAFLD outcomes through interactions with nutritional features. This knowledge may contribute to gaining a deeper understanding of the molecular and physiological processes underlying MAFLD pathogenesis and phenotype heterogeneity, as well as facilitating the identification of biomarkers of disease progression and therapeutic targets for the implementation of tailored nutritional strategies. This comprehensive literature review highlights the potential of nutrigenetic, nutriepigenetic, nutrimetagenomic, nutritranscriptomics, and nutrimetabolomic approaches for the prevention and management of MAFLD in humans through the lens of precision nutrition. |
format | Online Article Text |
id | pubmed-9690481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96904812022-11-25 Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease Ramos-Lopez, Omar Genes (Basel) Review Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. However, the onset and progression of MAFLD is variable among individuals, being influenced by intrinsic (personal) and external environmental factors. In this context, sequence structural variants across the human genome, epigenetic phenomena (i.e., DNA methylation, histone modifications, and long non-coding RNAs) affecting gene expression, gut microbiota dysbiosis, and metabolomics/lipidomic fingerprints may account for differences in MAFLD outcomes through interactions with nutritional features. This knowledge may contribute to gaining a deeper understanding of the molecular and physiological processes underlying MAFLD pathogenesis and phenotype heterogeneity, as well as facilitating the identification of biomarkers of disease progression and therapeutic targets for the implementation of tailored nutritional strategies. This comprehensive literature review highlights the potential of nutrigenetic, nutriepigenetic, nutrimetagenomic, nutritranscriptomics, and nutrimetabolomic approaches for the prevention and management of MAFLD in humans through the lens of precision nutrition. MDPI 2022-11-17 /pmc/articles/PMC9690481/ /pubmed/36421817 http://dx.doi.org/10.3390/genes13112142 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ramos-Lopez, Omar Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title | Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title_full | Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title_fullStr | Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title_full_unstemmed | Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title_short | Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease |
title_sort | multi-omics nutritional approaches targeting metabolic-associated fatty liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690481/ https://www.ncbi.nlm.nih.gov/pubmed/36421817 http://dx.doi.org/10.3390/genes13112142 |
work_keys_str_mv | AT ramoslopezomar multiomicsnutritionalapproachestargetingmetabolicassociatedfattyliverdisease |