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Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus

Sasang constitutional medicine is a traditional customized medicine in Korea that classifies people into four types: Taeeumin (TE), Taeyangin (TY), Soeumin (SE), and Soyangin (SY). This study explored whether Sasang constitution (SC) types combined with general obesity could be risk factors for pred...

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Autores principales: Baek, Younghwa, Lee, Siwoo, Jeong, Kyoungsik, Jang, Eunsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690487/
https://www.ncbi.nlm.nih.gov/pubmed/36421610
http://dx.doi.org/10.3390/healthcare10112286
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author Baek, Younghwa
Lee, Siwoo
Jeong, Kyoungsik
Jang, Eunsu
author_facet Baek, Younghwa
Lee, Siwoo
Jeong, Kyoungsik
Jang, Eunsu
author_sort Baek, Younghwa
collection PubMed
description Sasang constitutional medicine is a traditional customized medicine in Korea that classifies people into four types: Taeeumin (TE), Taeyangin (TY), Soeumin (SE), and Soyangin (SY). This study explored whether Sasang constitution (SC) types combined with general obesity could be risk factors for prediabetes mellitus (pre-DM). This study was cross-sectional and was conducted from November 2007 to July 2011 in 23 Korean medical clinics. In total, 2185 eligible subjects participated. A t test, one-way ANOVA with Scheffé’s post hoc analysis, the chi-square test and multinomial logistic regression were used. Significance was indicated by p < 0.05. The numbers of participants with normal fasting plasma glucose (FPG) levels and pre-DM were 405 (75.3%) and 133 (24.7%) in the SE, 516 (70.3%) and 218 (29.7%) in the SY, and 590 (64.6%) and 323 (35.4%) in the TE (p < 0.001) groups, respectively. There was a significant difference in the proportion of each SC type among people with pre-DM and normal FPG levels in the normal BMI group. The odds ratios (ORs) of the TE type were significantly different from those of the SE type in the crude and Model 1. The distribution of the normal FPG and pre-DM individuals between the obese and normal BMI groups only for the SY type was significantly different. The SY type combined with general obesity had a higher OR (1.846, 95% CI 1.286–2.649) than that combined with normal BMI among participants with pre-DM, and this higher OR remained after adjusting for covariates (OR, 1.604, 95% CI, 1.093–2.354). This study revealed that the TE type might be a risk factor for pre-DM in the normal BMI group, and the SY type with general obesity could be a risk factor for pre-DM compared with the SY type with normal BMI. Accordingly, SC and BMI should be considered when managing pre-DM. To clarify the risk of SC and BMI, further study including epigenetic factors is needed.
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spelling pubmed-96904872022-11-25 Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus Baek, Younghwa Lee, Siwoo Jeong, Kyoungsik Jang, Eunsu Healthcare (Basel) Article Sasang constitutional medicine is a traditional customized medicine in Korea that classifies people into four types: Taeeumin (TE), Taeyangin (TY), Soeumin (SE), and Soyangin (SY). This study explored whether Sasang constitution (SC) types combined with general obesity could be risk factors for prediabetes mellitus (pre-DM). This study was cross-sectional and was conducted from November 2007 to July 2011 in 23 Korean medical clinics. In total, 2185 eligible subjects participated. A t test, one-way ANOVA with Scheffé’s post hoc analysis, the chi-square test and multinomial logistic regression were used. Significance was indicated by p < 0.05. The numbers of participants with normal fasting plasma glucose (FPG) levels and pre-DM were 405 (75.3%) and 133 (24.7%) in the SE, 516 (70.3%) and 218 (29.7%) in the SY, and 590 (64.6%) and 323 (35.4%) in the TE (p < 0.001) groups, respectively. There was a significant difference in the proportion of each SC type among people with pre-DM and normal FPG levels in the normal BMI group. The odds ratios (ORs) of the TE type were significantly different from those of the SE type in the crude and Model 1. The distribution of the normal FPG and pre-DM individuals between the obese and normal BMI groups only for the SY type was significantly different. The SY type combined with general obesity had a higher OR (1.846, 95% CI 1.286–2.649) than that combined with normal BMI among participants with pre-DM, and this higher OR remained after adjusting for covariates (OR, 1.604, 95% CI, 1.093–2.354). This study revealed that the TE type might be a risk factor for pre-DM in the normal BMI group, and the SY type with general obesity could be a risk factor for pre-DM compared with the SY type with normal BMI. Accordingly, SC and BMI should be considered when managing pre-DM. To clarify the risk of SC and BMI, further study including epigenetic factors is needed. MDPI 2022-11-15 /pmc/articles/PMC9690487/ /pubmed/36421610 http://dx.doi.org/10.3390/healthcare10112286 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baek, Younghwa
Lee, Siwoo
Jeong, Kyoungsik
Jang, Eunsu
Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title_full Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title_fullStr Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title_full_unstemmed Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title_short Sasang Constitution Type Combined with General Obesity May Act as a Risk Factor for Prediabetes Mellitus
title_sort sasang constitution type combined with general obesity may act as a risk factor for prediabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690487/
https://www.ncbi.nlm.nih.gov/pubmed/36421610
http://dx.doi.org/10.3390/healthcare10112286
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