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Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population

Background: Several studies showed important differences in the interpretation of spirometry based on different reference values, in particular by comparing European Respiratory Society (ERS) 1993 and Global Lung Function Initiative (GLI) 2012. The validation of new reference values in local populat...

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Autores principales: Fontana, Luca, Cioffi, Dante Luigi, Leso, Veruscka, D’Ausilio, Emanuele, Pacella, Daniela, Fedele, Mauro, Maniscalco, Mauro, Iavicoli, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690579/
https://www.ncbi.nlm.nih.gov/pubmed/36429917
http://dx.doi.org/10.3390/ijerph192215200
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author Fontana, Luca
Cioffi, Dante Luigi
Leso, Veruscka
D’Ausilio, Emanuele
Pacella, Daniela
Fedele, Mauro
Maniscalco, Mauro
Iavicoli, Ivo
author_facet Fontana, Luca
Cioffi, Dante Luigi
Leso, Veruscka
D’Ausilio, Emanuele
Pacella, Daniela
Fedele, Mauro
Maniscalco, Mauro
Iavicoli, Ivo
author_sort Fontana, Luca
collection PubMed
description Background: Several studies showed important differences in the interpretation of spirometry based on different reference values, in particular by comparing European Respiratory Society (ERS) 1993 and Global Lung Function Initiative (GLI) 2012. The validation of new reference values in local populations is essential before they can be used in an appropriate manner. This study aimed to investigate the fit of GLI reference values in a healthy Italian working population. Methods: Spirometry data were collected in 1355 workers during their health surveillance medical examination conducted for exposure to chemical and biological risk factors. A single portable spirometer that met the ATS/ERS recommendations for occupational testing was used and calibrated daily. Results: Average z-score were −0.13 (with a median of −0.17), −0.25 (with a median of −0.24), and 0.18 (with a median of 0.17) for FEV(1), FVC, and FEV(1)/FVC ratio, respectively. Considering only the normal-weighted workers, the average z-scores were −0.07 (with a median of −0.16), −0.15 (with a median of −0.16), and 0.07 (with a median of 0.02) for FEV(1), FVC, and FEV(1)/FVC ratio, respectively. Conclusions: GLI 2012 reference values fit the Italian data satisfactorily, resulting as more accurate than ERS 1993, especially in women, normal-weighted subjects, aged 30−50 years, and for height < 165 cm.
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spelling pubmed-96905792022-11-25 Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population Fontana, Luca Cioffi, Dante Luigi Leso, Veruscka D’Ausilio, Emanuele Pacella, Daniela Fedele, Mauro Maniscalco, Mauro Iavicoli, Ivo Int J Environ Res Public Health Article Background: Several studies showed important differences in the interpretation of spirometry based on different reference values, in particular by comparing European Respiratory Society (ERS) 1993 and Global Lung Function Initiative (GLI) 2012. The validation of new reference values in local populations is essential before they can be used in an appropriate manner. This study aimed to investigate the fit of GLI reference values in a healthy Italian working population. Methods: Spirometry data were collected in 1355 workers during their health surveillance medical examination conducted for exposure to chemical and biological risk factors. A single portable spirometer that met the ATS/ERS recommendations for occupational testing was used and calibrated daily. Results: Average z-score were −0.13 (with a median of −0.17), −0.25 (with a median of −0.24), and 0.18 (with a median of 0.17) for FEV(1), FVC, and FEV(1)/FVC ratio, respectively. Considering only the normal-weighted workers, the average z-scores were −0.07 (with a median of −0.16), −0.15 (with a median of −0.16), and 0.07 (with a median of 0.02) for FEV(1), FVC, and FEV(1)/FVC ratio, respectively. Conclusions: GLI 2012 reference values fit the Italian data satisfactorily, resulting as more accurate than ERS 1993, especially in women, normal-weighted subjects, aged 30−50 years, and for height < 165 cm. MDPI 2022-11-17 /pmc/articles/PMC9690579/ /pubmed/36429917 http://dx.doi.org/10.3390/ijerph192215200 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fontana, Luca
Cioffi, Dante Luigi
Leso, Veruscka
D’Ausilio, Emanuele
Pacella, Daniela
Fedele, Mauro
Maniscalco, Mauro
Iavicoli, Ivo
Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title_full Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title_fullStr Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title_full_unstemmed Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title_short Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
title_sort validation of the global lung function initiative 2012 spirometry reference values in a healthy italian working population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690579/
https://www.ncbi.nlm.nih.gov/pubmed/36429917
http://dx.doi.org/10.3390/ijerph192215200
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