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The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-r...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690666/ https://www.ncbi.nlm.nih.gov/pubmed/36429783 http://dx.doi.org/10.3390/ijerph192215062 |
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author | Tocco Tussardi, Ilaria Tfaily, Ahmad Locatelli, Francesca Antonicelli, Leonardo Battaglia, Salvatore Bono, Roberto Corsico, Angelo G. Murgia, Nicola Pirina, Pietro Ferrari, Marcello Tardivo, Stefano Jarvis, Deborah L. Verlato, Giuseppe |
author_facet | Tocco Tussardi, Ilaria Tfaily, Ahmad Locatelli, Francesca Antonicelli, Leonardo Battaglia, Salvatore Bono, Roberto Corsico, Angelo G. Murgia, Nicola Pirina, Pietro Ferrari, Marcello Tardivo, Stefano Jarvis, Deborah L. Verlato, Giuseppe |
author_sort | Tocco Tussardi, Ilaria |
collection | PubMed |
description | Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%; p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p < 0.001). Although FEV1 and FVC were reduced in individuals with low BW, this was explained by associations with sex and height. In multivariable analysis, BW was not associated with respiratory diseases in adulthood. However, those with low BW had a higher risk of self-reported hospitalisation for lung disease before the age of two (10.3% vs. 4.1%; p < 0.001), severe respiratory infection before the age of five (16.9% vs. 8.8%; p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027). |
format | Online Article Text |
id | pubmed-9690666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96906662022-11-25 The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy Tocco Tussardi, Ilaria Tfaily, Ahmad Locatelli, Francesca Antonicelli, Leonardo Battaglia, Salvatore Bono, Roberto Corsico, Angelo G. Murgia, Nicola Pirina, Pietro Ferrari, Marcello Tardivo, Stefano Jarvis, Deborah L. Verlato, Giuseppe Int J Environ Res Public Health Article Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%; p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p < 0.001). Although FEV1 and FVC were reduced in individuals with low BW, this was explained by associations with sex and height. In multivariable analysis, BW was not associated with respiratory diseases in adulthood. However, those with low BW had a higher risk of self-reported hospitalisation for lung disease before the age of two (10.3% vs. 4.1%; p < 0.001), severe respiratory infection before the age of five (16.9% vs. 8.8%; p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027). MDPI 2022-11-16 /pmc/articles/PMC9690666/ /pubmed/36429783 http://dx.doi.org/10.3390/ijerph192215062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tocco Tussardi, Ilaria Tfaily, Ahmad Locatelli, Francesca Antonicelli, Leonardo Battaglia, Salvatore Bono, Roberto Corsico, Angelo G. Murgia, Nicola Pirina, Pietro Ferrari, Marcello Tardivo, Stefano Jarvis, Deborah L. Verlato, Giuseppe The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title | The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title_full | The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title_fullStr | The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title_full_unstemmed | The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title_short | The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy |
title_sort | association of self-reported birthweight with lung function and respiratory diseases: results from a multi-centre, multi-case control study in italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690666/ https://www.ncbi.nlm.nih.gov/pubmed/36429783 http://dx.doi.org/10.3390/ijerph192215062 |
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