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The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy

Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-r...

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Autores principales: Tocco Tussardi, Ilaria, Tfaily, Ahmad, Locatelli, Francesca, Antonicelli, Leonardo, Battaglia, Salvatore, Bono, Roberto, Corsico, Angelo G., Murgia, Nicola, Pirina, Pietro, Ferrari, Marcello, Tardivo, Stefano, Jarvis, Deborah L., Verlato, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690666/
https://www.ncbi.nlm.nih.gov/pubmed/36429783
http://dx.doi.org/10.3390/ijerph192215062
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author Tocco Tussardi, Ilaria
Tfaily, Ahmad
Locatelli, Francesca
Antonicelli, Leonardo
Battaglia, Salvatore
Bono, Roberto
Corsico, Angelo G.
Murgia, Nicola
Pirina, Pietro
Ferrari, Marcello
Tardivo, Stefano
Jarvis, Deborah L.
Verlato, Giuseppe
author_facet Tocco Tussardi, Ilaria
Tfaily, Ahmad
Locatelli, Francesca
Antonicelli, Leonardo
Battaglia, Salvatore
Bono, Roberto
Corsico, Angelo G.
Murgia, Nicola
Pirina, Pietro
Ferrari, Marcello
Tardivo, Stefano
Jarvis, Deborah L.
Verlato, Giuseppe
author_sort Tocco Tussardi, Ilaria
collection PubMed
description Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%; p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p < 0.001). Although FEV1 and FVC were reduced in individuals with low BW, this was explained by associations with sex and height. In multivariable analysis, BW was not associated with respiratory diseases in adulthood. However, those with low BW had a higher risk of self-reported hospitalisation for lung disease before the age of two (10.3% vs. 4.1%; p < 0.001), severe respiratory infection before the age of five (16.9% vs. 8.8%; p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027).
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spelling pubmed-96906662022-11-25 The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy Tocco Tussardi, Ilaria Tfaily, Ahmad Locatelli, Francesca Antonicelli, Leonardo Battaglia, Salvatore Bono, Roberto Corsico, Angelo G. Murgia, Nicola Pirina, Pietro Ferrari, Marcello Tardivo, Stefano Jarvis, Deborah L. Verlato, Giuseppe Int J Environ Res Public Health Article Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%; p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p < 0.001). Although FEV1 and FVC were reduced in individuals with low BW, this was explained by associations with sex and height. In multivariable analysis, BW was not associated with respiratory diseases in adulthood. However, those with low BW had a higher risk of self-reported hospitalisation for lung disease before the age of two (10.3% vs. 4.1%; p < 0.001), severe respiratory infection before the age of five (16.9% vs. 8.8%; p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027). MDPI 2022-11-16 /pmc/articles/PMC9690666/ /pubmed/36429783 http://dx.doi.org/10.3390/ijerph192215062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tocco Tussardi, Ilaria
Tfaily, Ahmad
Locatelli, Francesca
Antonicelli, Leonardo
Battaglia, Salvatore
Bono, Roberto
Corsico, Angelo G.
Murgia, Nicola
Pirina, Pietro
Ferrari, Marcello
Tardivo, Stefano
Jarvis, Deborah L.
Verlato, Giuseppe
The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title_full The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title_fullStr The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title_full_unstemmed The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title_short The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy
title_sort association of self-reported birthweight with lung function and respiratory diseases: results from a multi-centre, multi-case control study in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690666/
https://www.ncbi.nlm.nih.gov/pubmed/36429783
http://dx.doi.org/10.3390/ijerph192215062
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