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Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020

Respiratory syncytial virus (RSV) infection is increasingly recognized as a cause of significant morbidity and mortality in adults. We aimed to estimate the rates of age-specific hospitalization and in-hospital mortality caused by acute lower respiratory tract infections (ALRTIs) in Spain between 20...

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Autores principales: Heppe-Montero, Marco, Gil-Prieto, Ruth, del Diego Salas, Jorge, Hernández-Barrera, Valentín, Gil-de-Miguel, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690810/
https://www.ncbi.nlm.nih.gov/pubmed/36429399
http://dx.doi.org/10.3390/ijerph192214680
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author Heppe-Montero, Marco
Gil-Prieto, Ruth
del Diego Salas, Jorge
Hernández-Barrera, Valentín
Gil-de-Miguel, Ángel
author_facet Heppe-Montero, Marco
Gil-Prieto, Ruth
del Diego Salas, Jorge
Hernández-Barrera, Valentín
Gil-de-Miguel, Ángel
author_sort Heppe-Montero, Marco
collection PubMed
description Respiratory syncytial virus (RSV) infection is increasingly recognized as a cause of significant morbidity and mortality in adults. We aimed to estimate the rates of age-specific hospitalization and in-hospital mortality caused by acute lower respiratory tract infections (ALRTIs) in Spain between 2012 and 2020 and to compare the relative impact of RSV and influenza virus infection in adults. We used the discharge reports from the Minimum Basic Data Set to retrospectively analyze hospital discharge data on the basis of the ICD-9-CM and ICD-10-CM diagnosis codes. A total of 1,518,244 patients were hospitalized for ALRTIs, of whom 137,794 (9.1%) were admitted for RSV-related infections and 46,288 (3.0%) for influenza-related infections. In patients aged 60 years or older, the hospitalization rates (per 100,000 population) were estimated at 1.69 (95% CI 1.68–1.70) and 2.72 (95% CI 2.71–2.73) for RSV and influenza patients, respectively. However, in-hospital mortality rates were significantly higher among RSV patients than among influenza patients, 7.91% (95% CI 7.89–7.93) (83.0% of all RSV-related deaths) versus 6.91% (95% CI 6.89–6.93) (85.6% of all influenza-related deaths), respectively (p = 0.007). RSV-associated in-hospital mortality increases exponentially with age, posing a greater risk for older adults, particularly frail and high-risk patients.
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spelling pubmed-96908102022-11-25 Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020 Heppe-Montero, Marco Gil-Prieto, Ruth del Diego Salas, Jorge Hernández-Barrera, Valentín Gil-de-Miguel, Ángel Int J Environ Res Public Health Article Respiratory syncytial virus (RSV) infection is increasingly recognized as a cause of significant morbidity and mortality in adults. We aimed to estimate the rates of age-specific hospitalization and in-hospital mortality caused by acute lower respiratory tract infections (ALRTIs) in Spain between 2012 and 2020 and to compare the relative impact of RSV and influenza virus infection in adults. We used the discharge reports from the Minimum Basic Data Set to retrospectively analyze hospital discharge data on the basis of the ICD-9-CM and ICD-10-CM diagnosis codes. A total of 1,518,244 patients were hospitalized for ALRTIs, of whom 137,794 (9.1%) were admitted for RSV-related infections and 46,288 (3.0%) for influenza-related infections. In patients aged 60 years or older, the hospitalization rates (per 100,000 population) were estimated at 1.69 (95% CI 1.68–1.70) and 2.72 (95% CI 2.71–2.73) for RSV and influenza patients, respectively. However, in-hospital mortality rates were significantly higher among RSV patients than among influenza patients, 7.91% (95% CI 7.89–7.93) (83.0% of all RSV-related deaths) versus 6.91% (95% CI 6.89–6.93) (85.6% of all influenza-related deaths), respectively (p = 0.007). RSV-associated in-hospital mortality increases exponentially with age, posing a greater risk for older adults, particularly frail and high-risk patients. MDPI 2022-11-09 /pmc/articles/PMC9690810/ /pubmed/36429399 http://dx.doi.org/10.3390/ijerph192214680 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heppe-Montero, Marco
Gil-Prieto, Ruth
del Diego Salas, Jorge
Hernández-Barrera, Valentín
Gil-de-Miguel, Ángel
Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title_full Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title_fullStr Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title_full_unstemmed Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title_short Impact of Respiratory Syncytial Virus and Influenza Virus Infection in the Adult Population in Spain between 2012 and 2020
title_sort impact of respiratory syncytial virus and influenza virus infection in the adult population in spain between 2012 and 2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690810/
https://www.ncbi.nlm.nih.gov/pubmed/36429399
http://dx.doi.org/10.3390/ijerph192214680
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