CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of...

Descripción completa

Detalles Bibliográficos
Autores principales: Almeida, Renata Sanches, Wisnieski, Fernanda, Takao Real Karia, Bruno, Smith, Marilia Arruda Cardoso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690943/
https://www.ncbi.nlm.nih.gov/pubmed/36360266
http://dx.doi.org/10.3390/genes13112029
_version_ 1784836920825610240
author Almeida, Renata Sanches
Wisnieski, Fernanda
Takao Real Karia, Bruno
Smith, Marilia Arruda Cardoso
author_facet Almeida, Renata Sanches
Wisnieski, Fernanda
Takao Real Karia, Bruno
Smith, Marilia Arruda Cardoso
author_sort Almeida, Renata Sanches
collection PubMed
description Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research.
format Online
Article
Text
id pubmed-9690943
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96909432022-11-25 CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer Almeida, Renata Sanches Wisnieski, Fernanda Takao Real Karia, Bruno Smith, Marilia Arruda Cardoso Genes (Basel) Review Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research. MDPI 2022-11-04 /pmc/articles/PMC9690943/ /pubmed/36360266 http://dx.doi.org/10.3390/genes13112029 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Almeida, Renata Sanches
Wisnieski, Fernanda
Takao Real Karia, Bruno
Smith, Marilia Arruda Cardoso
CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title_full CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title_fullStr CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title_full_unstemmed CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title_short CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
title_sort crispr/cas9 genome-editing technology and potential clinical application in gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690943/
https://www.ncbi.nlm.nih.gov/pubmed/36360266
http://dx.doi.org/10.3390/genes13112029
work_keys_str_mv AT almeidarenatasanches crisprcas9genomeeditingtechnologyandpotentialclinicalapplicationingastriccancer
AT wisnieskifernanda crisprcas9genomeeditingtechnologyandpotentialclinicalapplicationingastriccancer
AT takaorealkariabruno crisprcas9genomeeditingtechnologyandpotentialclinicalapplicationingastriccancer
AT smithmariliaarrudacardoso crisprcas9genomeeditingtechnologyandpotentialclinicalapplicationingastriccancer

Ejemplares similares