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Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia
A 2-year prospective study carried out on ventilator-associated pneumonia (VAP) patients in the intensive care unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia (KSA), revealed a high prevalence of extremely drug-resistant (XDR) Acinetobacter baumannii. About a 9% increase in the incid...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690950/ https://www.ncbi.nlm.nih.gov/pubmed/36360551 http://dx.doi.org/10.3390/healthcare10112210 |
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author | Saleem, Mohd Syed Khaja, Azharuddin Sajid Hossain, Ashfaque Alenazi, Fahaad Said, Kamaleldin B. Moursi, Soha Abdallah Almalaq, Homoud Abdulmohsin Mohamed, Hamza Rakha, Ehab |
author_facet | Saleem, Mohd Syed Khaja, Azharuddin Sajid Hossain, Ashfaque Alenazi, Fahaad Said, Kamaleldin B. Moursi, Soha Abdallah Almalaq, Homoud Abdulmohsin Mohamed, Hamza Rakha, Ehab |
author_sort | Saleem, Mohd |
collection | PubMed |
description | A 2-year prospective study carried out on ventilator-associated pneumonia (VAP) patients in the intensive care unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia (KSA), revealed a high prevalence of extremely drug-resistant (XDR) Acinetobacter baumannii. About a 9% increase in the incidence rate of A. baumannii occurred in the VAP patients between 2019 and 2020 (21.4% to 30.7%). In 2019, the isolates were positive for IMP-1 and VIM-2 (31.1% and 25.7%, respectively) as detected by PCR. In comparison, a higher proportion of isolates produced NDM-1 in 2020. Here, we observed a high proportion of resistant ICU isolates towards the most common antibiotics in use. Colistin sensitivity dropped to 91.4% in the year 2020 as compared to 2019 (100%). Thus, the finding of this study has a highly significant clinical implementation in the clinical management strategies for VAP patients. Furthermore, strict implementation of antibiotic stewardship policies, regular surveillance programs for antimicrobial resistance monitoring, and screening for genes encoding drug resistance phenotypes have become imperative. |
format | Online Article Text |
id | pubmed-9690950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96909502022-11-25 Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia Saleem, Mohd Syed Khaja, Azharuddin Sajid Hossain, Ashfaque Alenazi, Fahaad Said, Kamaleldin B. Moursi, Soha Abdallah Almalaq, Homoud Abdulmohsin Mohamed, Hamza Rakha, Ehab Healthcare (Basel) Article A 2-year prospective study carried out on ventilator-associated pneumonia (VAP) patients in the intensive care unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia (KSA), revealed a high prevalence of extremely drug-resistant (XDR) Acinetobacter baumannii. About a 9% increase in the incidence rate of A. baumannii occurred in the VAP patients between 2019 and 2020 (21.4% to 30.7%). In 2019, the isolates were positive for IMP-1 and VIM-2 (31.1% and 25.7%, respectively) as detected by PCR. In comparison, a higher proportion of isolates produced NDM-1 in 2020. Here, we observed a high proportion of resistant ICU isolates towards the most common antibiotics in use. Colistin sensitivity dropped to 91.4% in the year 2020 as compared to 2019 (100%). Thus, the finding of this study has a highly significant clinical implementation in the clinical management strategies for VAP patients. Furthermore, strict implementation of antibiotic stewardship policies, regular surveillance programs for antimicrobial resistance monitoring, and screening for genes encoding drug resistance phenotypes have become imperative. MDPI 2022-11-03 /pmc/articles/PMC9690950/ /pubmed/36360551 http://dx.doi.org/10.3390/healthcare10112210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saleem, Mohd Syed Khaja, Azharuddin Sajid Hossain, Ashfaque Alenazi, Fahaad Said, Kamaleldin B. Moursi, Soha Abdallah Almalaq, Homoud Abdulmohsin Mohamed, Hamza Rakha, Ehab Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title | Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title_full | Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title_fullStr | Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title_full_unstemmed | Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title_short | Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia |
title_sort | molecular characterization and antibiogram of acinetobacter baumannii clinical isolates recovered from the patients with ventilator-associated pneumonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690950/ https://www.ncbi.nlm.nih.gov/pubmed/36360551 http://dx.doi.org/10.3390/healthcare10112210 |
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