Cargando…

Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature

Introduction: Type 2 diabetes mellitus (T2DM) has been associated with higher rates and poorer prognosis of infections, mainly due to poor glycemic control, reduced response of T-cells and neutrophils, and impaired migration, phagocytosis, and chemotaxis of leukocytes. However, the impact of T2DM on...

Descripción completa

Detalles Bibliográficos
Autores principales: Cozma, Matei-Alexandru, Dobrică, Elena-Codruta, Shah, Purva, Shellah, Duha, Găman, Mihnea-Alexandru, Diaconu, Camelia Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691116/
https://www.ncbi.nlm.nih.gov/pubmed/36360537
http://dx.doi.org/10.3390/healthcare10112196
_version_ 1784836964604706816
author Cozma, Matei-Alexandru
Dobrică, Elena-Codruta
Shah, Purva
Shellah, Duha
Găman, Mihnea-Alexandru
Diaconu, Camelia Cristina
author_facet Cozma, Matei-Alexandru
Dobrică, Elena-Codruta
Shah, Purva
Shellah, Duha
Găman, Mihnea-Alexandru
Diaconu, Camelia Cristina
author_sort Cozma, Matei-Alexandru
collection PubMed
description Introduction: Type 2 diabetes mellitus (T2DM) has been associated with higher rates and poorer prognosis of infections, mainly due to poor glycemic control, reduced response of T-cells and neutrophils, and impaired migration, phagocytosis, and chemotaxis of leukocytes. However, the impact of T2DM on acute cholangitis (AC) has not been assessed so far. Thus, we aimed to explore this association by means of a systematic review of the literature. Methods: This systematic review was carried out based on the recommendations stated in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the PubMed/MEDLINE, Web of Science and SCOPUS databases to identify relevant publications depicting an association between T2DM and AC from the inception of these search services up to present. Results: We detected a total of 435 eligible records. After we applied the inclusion and exclusion criteria, a total of 14 articles were included in the present systematic review. Included manuscripts focused on the potential role of T2DM as a risk factor for the development of AC and on its contribution to a worse prognosis in AC, e.g., development of sepsis or other complications, the risk of AC recurrence and the impact on mortality. Conclusions: As compared to non-diabetic individuals, patients with T2DM have a higher risk of AC as a complication of choledocholithiasis or gallstone pancreatitis. Several oral hypoglycemic drugs used in the management of T2DM may also be involved in the onset of AC. Diabetic patients who suffer from AC have a higher likelihood of longer hospital stays and sepsis, as well as a higher risk of mortality and more severe forms of AC as compared to non-diabetic individuals.
format Online
Article
Text
id pubmed-9691116
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96911162022-11-25 Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature Cozma, Matei-Alexandru Dobrică, Elena-Codruta Shah, Purva Shellah, Duha Găman, Mihnea-Alexandru Diaconu, Camelia Cristina Healthcare (Basel) Systematic Review Introduction: Type 2 diabetes mellitus (T2DM) has been associated with higher rates and poorer prognosis of infections, mainly due to poor glycemic control, reduced response of T-cells and neutrophils, and impaired migration, phagocytosis, and chemotaxis of leukocytes. However, the impact of T2DM on acute cholangitis (AC) has not been assessed so far. Thus, we aimed to explore this association by means of a systematic review of the literature. Methods: This systematic review was carried out based on the recommendations stated in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the PubMed/MEDLINE, Web of Science and SCOPUS databases to identify relevant publications depicting an association between T2DM and AC from the inception of these search services up to present. Results: We detected a total of 435 eligible records. After we applied the inclusion and exclusion criteria, a total of 14 articles were included in the present systematic review. Included manuscripts focused on the potential role of T2DM as a risk factor for the development of AC and on its contribution to a worse prognosis in AC, e.g., development of sepsis or other complications, the risk of AC recurrence and the impact on mortality. Conclusions: As compared to non-diabetic individuals, patients with T2DM have a higher risk of AC as a complication of choledocholithiasis or gallstone pancreatitis. Several oral hypoglycemic drugs used in the management of T2DM may also be involved in the onset of AC. Diabetic patients who suffer from AC have a higher likelihood of longer hospital stays and sepsis, as well as a higher risk of mortality and more severe forms of AC as compared to non-diabetic individuals. MDPI 2022-11-02 /pmc/articles/PMC9691116/ /pubmed/36360537 http://dx.doi.org/10.3390/healthcare10112196 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Cozma, Matei-Alexandru
Dobrică, Elena-Codruta
Shah, Purva
Shellah, Duha
Găman, Mihnea-Alexandru
Diaconu, Camelia Cristina
Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title_full Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title_fullStr Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title_full_unstemmed Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title_short Implications of Type 2 Diabetes Mellitus in Patients with Acute Cholangitis: A Systematic Review of Current Literature
title_sort implications of type 2 diabetes mellitus in patients with acute cholangitis: a systematic review of current literature
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691116/
https://www.ncbi.nlm.nih.gov/pubmed/36360537
http://dx.doi.org/10.3390/healthcare10112196
work_keys_str_mv AT cozmamateialexandru implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature
AT dobricaelenacodruta implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature
AT shahpurva implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature
AT shellahduha implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature
AT gamanmihneaalexandru implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature
AT diaconucameliacristina implicationsoftype2diabetesmellitusinpatientswithacutecholangitisasystematicreviewofcurrentliterature