Cargando…
Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”
BACKGROUND: Prolonged cognitive deficits (“brain fog”) following COVID19 infection (long-COVID) are common and debilitating, yet there are currently no approved treatments. Cognitive impairment particularly targets the working memory and executive functions of the prefrontal cortex (PFC). The PFC ha...
Autores principales: | Fesharaki-Zadeh, Arman, Lowe, Naomi, Arnsten, Amy F.T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691274/ http://dx.doi.org/10.1016/j.nerep.2022.100154 |
Ejemplares similares
-
Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress
por: Hains, Avis Brennan, et al.
Publicado: (2015) -
Guanfacine for the Treatment of Cognitive Disorders: A Century of
Discoveries at Yale
por: Arnsten, Amy F.T., et al.
Publicado: (2012) -
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID
por: Fesharaki Zadeh, Arman, et al.
Publicado: (2023) -
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species
por: Arnsten, Amy F.T.
Publicado: (2020) -
Methylphenidate improves prefrontal cortical cognitive function through α2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder
por: Arnsten, Amy FT, et al.
Publicado: (2005)