The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth

Rationale: Primary and acquired resistance to Smoothened (Smo) inhibitors largely hampered their clinical efficacy. Given the important functions of hedgehog (Hh) pathway in bone formation and development, the permanent defects in bone growth caused by Smo inhibitors further restrict the use of Smo...

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Detalles Bibliográficos
Autores principales: Zhang, Shaoqing, Chen, Yue, Xu, Zhongli, Yang, Jun, Sun, Renhong, Wang, Juan, Sun, Yiming, Jiang, Biao, Yang, Xiaobao, Tan, Wenfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691367/
https://www.ncbi.nlm.nih.gov/pubmed/36438482
http://dx.doi.org/10.7150/thno.75421

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