Estrogen receptor α regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity

Vascular remodeling during microgravity exposure results in postflight cardiovascular deconditioning and orthostatic intolerance in astronauts. To clarify the underlying mechanism, we investigated whether estrogen receptor α (ERα)-NRF1-OMI-mitophagy signaling was involved in the dedifferentiation an...

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Detalles Bibliográficos
Autores principales: Jiang, Min, Liu, Zifan, Shao, Junjie, Zhou, Jingjing, Wang, Haiming, Song, Chao, Li, Xin, Wang, Lin, Xu, Qiang, Liu, Xiaojuan, Lin, Lejian, Zhang, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691402/
https://www.ncbi.nlm.nih.gov/pubmed/36439260
http://dx.doi.org/10.3389/fphys.2022.1039913

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