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A case of renal involvement in juvenile xanthogranulomatosis
Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound show...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691423/ https://www.ncbi.nlm.nih.gov/pubmed/36439921 http://dx.doi.org/10.1016/j.radcr.2022.10.101 |
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author | Shibuki, Saki Saida, Tsukasa Kamimaki, Takashi Takei, Yohei Kandori, Shuya Nishiyama, Hiroyuki Nakajima, Takahito |
author_facet | Shibuki, Saki Saida, Tsukasa Kamimaki, Takashi Takei, Yohei Kandori, Shuya Nishiyama, Hiroyuki Nakajima, Takahito |
author_sort | Shibuki, Saki |
collection | PubMed |
description | Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound showed multiple cystic masses with fine internal septa in both kidneys. Contrast-enhanced US revealed early staining and late washout consistent with the internal septa inside the masses and led us to suspect cystic renal cell carcinomas in both kidneys. Left nephrectomy was performed for diagnostic purposes. Microscopic examination revealed a foamy component with Touton-type giant cells by histiocytosis; CD68 and S100 were positive, and CD1a was negative, leading the diagnosis of JXD. The US findings of extracutaneous lesions on JXA are variable and can be cystic, and when arising in the kidney may resemble cystic renal cell carcinoma. |
format | Online Article Text |
id | pubmed-9691423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96914232022-11-26 A case of renal involvement in juvenile xanthogranulomatosis Shibuki, Saki Saida, Tsukasa Kamimaki, Takashi Takei, Yohei Kandori, Shuya Nishiyama, Hiroyuki Nakajima, Takahito Radiol Case Rep Case Report Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound showed multiple cystic masses with fine internal septa in both kidneys. Contrast-enhanced US revealed early staining and late washout consistent with the internal septa inside the masses and led us to suspect cystic renal cell carcinomas in both kidneys. Left nephrectomy was performed for diagnostic purposes. Microscopic examination revealed a foamy component with Touton-type giant cells by histiocytosis; CD68 and S100 were positive, and CD1a was negative, leading the diagnosis of JXD. The US findings of extracutaneous lesions on JXA are variable and can be cystic, and when arising in the kidney may resemble cystic renal cell carcinoma. Elsevier 2022-11-23 /pmc/articles/PMC9691423/ /pubmed/36439921 http://dx.doi.org/10.1016/j.radcr.2022.10.101 Text en © 2022 Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Shibuki, Saki Saida, Tsukasa Kamimaki, Takashi Takei, Yohei Kandori, Shuya Nishiyama, Hiroyuki Nakajima, Takahito A case of renal involvement in juvenile xanthogranulomatosis |
title | A case of renal involvement in juvenile xanthogranulomatosis |
title_full | A case of renal involvement in juvenile xanthogranulomatosis |
title_fullStr | A case of renal involvement in juvenile xanthogranulomatosis |
title_full_unstemmed | A case of renal involvement in juvenile xanthogranulomatosis |
title_short | A case of renal involvement in juvenile xanthogranulomatosis |
title_sort | case of renal involvement in juvenile xanthogranulomatosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691423/ https://www.ncbi.nlm.nih.gov/pubmed/36439921 http://dx.doi.org/10.1016/j.radcr.2022.10.101 |
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