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The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)

OBJECTIVE: Approximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal‐R) is the most common approach to treating obesity, yet clinically m...

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Autores principales: Gabel, Kelsey, Fitzgibbon, Marian L., Yazici, Cemal, Gann, Peter, Sverdlov, Maria, Guzman, Grace, Chen, Zhengjia, McLeod, Andrew, Hamm, Alyshia, Varady, Krista A., Tussing‐Humphreys, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691536/
https://www.ncbi.nlm.nih.gov/pubmed/36319597
http://dx.doi.org/10.1002/oby.23579
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author Gabel, Kelsey
Fitzgibbon, Marian L.
Yazici, Cemal
Gann, Peter
Sverdlov, Maria
Guzman, Grace
Chen, Zhengjia
McLeod, Andrew
Hamm, Alyshia
Varady, Krista A.
Tussing‐Humphreys, Lisa
author_facet Gabel, Kelsey
Fitzgibbon, Marian L.
Yazici, Cemal
Gann, Peter
Sverdlov, Maria
Guzman, Grace
Chen, Zhengjia
McLeod, Andrew
Hamm, Alyshia
Varady, Krista A.
Tussing‐Humphreys, Lisa
author_sort Gabel, Kelsey
collection PubMed
description OBJECTIVE: Approximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal‐R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time‐restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects. METHODS: The authors describe a 12‐month randomized controlled trial of 8‐hour TRE (ad libitum 12 PM‐8 PM), Cal‐R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity. RESULTS: Effects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight/composition and CRC risk markers. CONCLUSIONS: This study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity.
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spelling pubmed-96915362023-01-10 The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial) Gabel, Kelsey Fitzgibbon, Marian L. Yazici, Cemal Gann, Peter Sverdlov, Maria Guzman, Grace Chen, Zhengjia McLeod, Andrew Hamm, Alyshia Varady, Krista A. Tussing‐Humphreys, Lisa Obesity (Silver Spring) ORIGINAL ARTICLES OBJECTIVE: Approximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal‐R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time‐restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects. METHODS: The authors describe a 12‐month randomized controlled trial of 8‐hour TRE (ad libitum 12 PM‐8 PM), Cal‐R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity. RESULTS: Effects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight/composition and CRC risk markers. CONCLUSIONS: This study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity. John Wiley and Sons Inc. 2022-11-01 2022-12 /pmc/articles/PMC9691536/ /pubmed/36319597 http://dx.doi.org/10.1002/oby.23579 Text en © 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle ORIGINAL ARTICLES
Gabel, Kelsey
Fitzgibbon, Marian L.
Yazici, Cemal
Gann, Peter
Sverdlov, Maria
Guzman, Grace
Chen, Zhengjia
McLeod, Andrew
Hamm, Alyshia
Varady, Krista A.
Tussing‐Humphreys, Lisa
The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title_full The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title_fullStr The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title_full_unstemmed The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title_short The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
title_sort basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (tre‐crc trial)
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691536/
https://www.ncbi.nlm.nih.gov/pubmed/36319597
http://dx.doi.org/10.1002/oby.23579
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