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Neural pathways in nutrient sensing and insulin signaling
Nutrient sensing and metabolic homeostasis play an important role in the proper growth and development of an organism, and also in the energy intensive process of reproduction. Signals in response to nutritional and metabolic status is received and integrated by the brain to ensure homeostasis. In D...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691681/ https://www.ncbi.nlm.nih.gov/pubmed/36439265 http://dx.doi.org/10.3389/fphys.2022.1002183 |
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author | Ratnaparkhi, Anuradha Sudhakaran, Jyothish |
author_facet | Ratnaparkhi, Anuradha Sudhakaran, Jyothish |
author_sort | Ratnaparkhi, Anuradha |
collection | PubMed |
description | Nutrient sensing and metabolic homeostasis play an important role in the proper growth and development of an organism, and also in the energy intensive process of reproduction. Signals in response to nutritional and metabolic status is received and integrated by the brain to ensure homeostasis. In Drosophila, the fat body is one of the key organs involved in energy and nutrient sensing, storage and utilization. It also relays the nutritional status of the animal to the brain, activating specific circuits which modulate the synthesis and release of insulin-like peptides to regulate metabolism. Here, we review the molecular and cellular mechanisms involved in nutrient sensing with an emphasis on the neural pathways that modulate this process and discuss some of the open questions that need to be addressed. |
format | Online Article Text |
id | pubmed-9691681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96916812022-11-26 Neural pathways in nutrient sensing and insulin signaling Ratnaparkhi, Anuradha Sudhakaran, Jyothish Front Physiol Physiology Nutrient sensing and metabolic homeostasis play an important role in the proper growth and development of an organism, and also in the energy intensive process of reproduction. Signals in response to nutritional and metabolic status is received and integrated by the brain to ensure homeostasis. In Drosophila, the fat body is one of the key organs involved in energy and nutrient sensing, storage and utilization. It also relays the nutritional status of the animal to the brain, activating specific circuits which modulate the synthesis and release of insulin-like peptides to regulate metabolism. Here, we review the molecular and cellular mechanisms involved in nutrient sensing with an emphasis on the neural pathways that modulate this process and discuss some of the open questions that need to be addressed. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9691681/ /pubmed/36439265 http://dx.doi.org/10.3389/fphys.2022.1002183 Text en Copyright © 2022 Ratnaparkhi and Sudhakaran. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Ratnaparkhi, Anuradha Sudhakaran, Jyothish Neural pathways in nutrient sensing and insulin signaling |
title | Neural pathways in nutrient sensing and insulin signaling |
title_full | Neural pathways in nutrient sensing and insulin signaling |
title_fullStr | Neural pathways in nutrient sensing and insulin signaling |
title_full_unstemmed | Neural pathways in nutrient sensing and insulin signaling |
title_short | Neural pathways in nutrient sensing and insulin signaling |
title_sort | neural pathways in nutrient sensing and insulin signaling |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691681/ https://www.ncbi.nlm.nih.gov/pubmed/36439265 http://dx.doi.org/10.3389/fphys.2022.1002183 |
work_keys_str_mv | AT ratnaparkhianuradha neuralpathwaysinnutrientsensingandinsulinsignaling AT sudhakaranjyothish neuralpathwaysinnutrientsensingandinsulinsignaling |