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Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer

OBJECTIVES: The study investigated whether wedge resection plus adequate lymph nodes resection conferred comparable survival to lobectomy for node-negative non-small cell lung cancer (NSCLC) ≤2 cm. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify patients diagno...

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Autores principales: Ding, Hongdou, Song, Nan, Zhang, Peng, Jiang, Gening, Wang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691685/
https://www.ncbi.nlm.nih.gov/pubmed/36439429
http://dx.doi.org/10.3389/fonc.2022.1022904
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author Ding, Hongdou
Song, Nan
Zhang, Peng
Jiang, Gening
Wang, Haifeng
author_facet Ding, Hongdou
Song, Nan
Zhang, Peng
Jiang, Gening
Wang, Haifeng
author_sort Ding, Hongdou
collection PubMed
description OBJECTIVES: The study investigated whether wedge resection plus adequate lymph nodes resection conferred comparable survival to lobectomy for node-negative non-small cell lung cancer (NSCLC) ≤2 cm. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify patients diagnosed with node-negative NSCLC ≤2 cm and underwent wedge resection or lobectomy (2004-2015). Patients were stratified by the procedure (wedge resection, lobectomy) and the size of NSCLC (≤1 cm, 1-2 cm). We assessed survival between patients undergoing wedge resection and lobectomy. The optimal number of lymph nodes resected which made those two procedures comparable was explored by using Kaplan-Meier analysis and Cox regression analysis. Propensity score matching was performed to minimize the effect of confounding factors. RESULTS: 7893 patients with lobectomy and 2536 patients with wedge resection were identified. Wedge resection was associated with worse survival either in the ≤1 cm or 1-2 cm NSCLC before and after matching. For lesions 1-2 cm and receiving lobectomy, more lymph nodes resected conferred statistically significant increase on survival and six nodes were optimal. For lesions ≤1 cm and receiving lobectomy, lymph nodes resection had no impact on survival. Wedge resection and lobectomy were comparable when one or more nodes for lesions ≤1 cm and six or more nodes for lesions 1-2 cm were resected. CONCLUSIONS: Wedge resection was inferior to lobectomy for NSCLC ≤1 cm and 1-2 cm. Wedge resection plus adequate lymph nodes resection was comparable to lobectomy.
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spelling pubmed-96916852022-11-26 Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer Ding, Hongdou Song, Nan Zhang, Peng Jiang, Gening Wang, Haifeng Front Oncol Oncology OBJECTIVES: The study investigated whether wedge resection plus adequate lymph nodes resection conferred comparable survival to lobectomy for node-negative non-small cell lung cancer (NSCLC) ≤2 cm. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify patients diagnosed with node-negative NSCLC ≤2 cm and underwent wedge resection or lobectomy (2004-2015). Patients were stratified by the procedure (wedge resection, lobectomy) and the size of NSCLC (≤1 cm, 1-2 cm). We assessed survival between patients undergoing wedge resection and lobectomy. The optimal number of lymph nodes resected which made those two procedures comparable was explored by using Kaplan-Meier analysis and Cox regression analysis. Propensity score matching was performed to minimize the effect of confounding factors. RESULTS: 7893 patients with lobectomy and 2536 patients with wedge resection were identified. Wedge resection was associated with worse survival either in the ≤1 cm or 1-2 cm NSCLC before and after matching. For lesions 1-2 cm and receiving lobectomy, more lymph nodes resected conferred statistically significant increase on survival and six nodes were optimal. For lesions ≤1 cm and receiving lobectomy, lymph nodes resection had no impact on survival. Wedge resection and lobectomy were comparable when one or more nodes for lesions ≤1 cm and six or more nodes for lesions 1-2 cm were resected. CONCLUSIONS: Wedge resection was inferior to lobectomy for NSCLC ≤1 cm and 1-2 cm. Wedge resection plus adequate lymph nodes resection was comparable to lobectomy. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9691685/ /pubmed/36439429 http://dx.doi.org/10.3389/fonc.2022.1022904 Text en Copyright © 2022 Ding, Song, Zhang, Jiang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ding, Hongdou
Song, Nan
Zhang, Peng
Jiang, Gening
Wang, Haifeng
Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title_full Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title_fullStr Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title_full_unstemmed Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title_short Wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
title_sort wedge resection plus adequate lymph nodes resection is comparable to lobectomy for small-sized non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691685/
https://www.ncbi.nlm.nih.gov/pubmed/36439429
http://dx.doi.org/10.3389/fonc.2022.1022904
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